Interferon Alpha for Refractory Pseudophakic Cystoid Macular Edema (Irvine-Gass Syndrome)

被引：15

作者：

Dimopoulos, Spyridon ^{[1
]}

Deuter, Christoph M. E. ^{[1
]}

Blumenstock, Gunnar ^{[2
]}

Zierhut, Manfred ^{[1
]}

Dimopoulou, Anastasia ^{[1
]}

Voykov, Bogomil ^{[1
]}

Bartz-Schmidt, Karl-Ulrich ^{[1
]}

Doycheva, Deshka ^{[1
]}

机构：

[1] Univ Hosp Tuebingen, Ctr Ophthalmol, Elfriede Aulhorn Str 7, D-72076 Tubingen, Germany

[2] Eberhard Karls Univ Tuebingen, Inst Clin Epidemiol & Appl Biometry, Tubingen, Germany

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2020年 / 28卷 / 02期

关键词：

Cataract surgery; interferon alpha; Irvine-Gass syndrome; macular edema; treatment; RISK-FACTORS; SURGERY; PHACOEMULSIFICATION;

D O I：

10.1080/09273948.2019.1585883

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To assess the efficacy and safety of systemic interferon alpha-2a (IFN) for refractory pseudophakic cystoid macular edema (PCME). Methods: Retrospective observational study. The primary outcome was the decrease of central retinal thickness (CRT). Secondary endpoints were the improvement of best-corrected visual acuity (BCVA) and the assessment of IFN-related side effects. Results: Twenty-four eyes of 20 patients were included. The median CRT was 513 mu m (range 220-980 mu m) at baseline and decreased to 190 mu m (range 140-520 mu m) at the last follow-up visit (p < 0.001). Reduction of CRT greater than 100 mu m was observed in 22 eyes (92%). The median BCVA (logMAR) increased statistically significant from 0.5 (range 0.2-1.5) at baseline to 0.3 (0-0.8) at the last follow-up (p < 0.001). The BCVA improved in 18 eyes (75%) and remained stable in five eyes (21%). No severe treatment-related side effects occurred. Conclusion: IFN is a very effective agent for treatment of refractory PCME.

引用

页码：315 / 321

页数：7

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