MiRNAs and neural stem cells A team to treat parkinson disease?

被引:14
作者
Palm, Thomas [1 ]
Bahnassawy, Lamia'a [1 ]
Schwamborn, Jens C. [1 ]
机构
[1] Univ Munster, Inst Cell Biol, Munster, Germany
关键词
Parkinson's disease; neural stem cells; regeneration; differentiation; micro-RNA; MUTANT ALPHA-SYNUCLEIN; FIBROBLAST-GROWTH-FACTOR; NUCLEAR RECEPTOR TLX; MICRORNA EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; PROGENITOR CELLS; CONDITIONAL LOSS; MESSENGER-RNA; BRAIN-INJURY; SELF-RENEWAL;
D O I
10.4161/rna.19984
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Parkinson disease (PD) is a common neurodegenerative disorder with no proven neuroprotective or neurorestorative therapies. During disease progression, degeneration of dopaminergic neurons of the central nervous system occurs. Therefore, therapies that either aim on the inhibition of this degeneration or on the replacement of the degenerated neurons are needed. On the one hand, arrest of degeneration might be achievable through specific inhibition of disease associated genes like a-Synuclein or Leucine rich repeat kinase 2 (LRRK2). On the other hand, based on neural stem cells that bear the ability to generate new dopaminergic neurons, replacement of degenerated cells could be accomplished. Since both approaches can be regulated by micro-RNAs, these molecules have an enormous therapeutic potential. In this review, we will focus on the neurobiological and neurodegenerative implications of miRNAs and highlight their role in stem cell fate decisions. Finally, we will discuss their potential as therapeutic agents and targets for Parkinson disease.
引用
收藏
页码:720 / 730
页数:11
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