Palladium-Catalyzed Enantioselective Decarboxylative Allylic Alkylation of Acyclic α-N-Pyrrolyl/Indolyl Ketones

被引：14

作者：

Lavernhe, Remi ^{[1
]}

Alexy, Eric J. ^{[1
]}

Zhang, Haiming ^{[2
]}

Stoltz, Brian M. ^{[1
]}

机构：

[1] CALTECH, Warren & Katharine Schlinger Lab Chem & Chem Engn, Div Chem & Chem Engn, Pasadena, CA 91125 USA

[2] Genentech Inc, Small Mol Proc Chem, San Francisco, CA 94080 USA

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 11期

基金：

美国国家科学基金会;

关键词：

INDOLES; CONSTRUCTION; PYRROLE;

D O I：

10.1021/acs.orglett.0c01303

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of fully substituted alpha-N-pyrrolyl and indolyl ketones via enantioselective palladium-catalyzed allylic alkylation is described. The acyclic ketones are alkylated in high yields with high enantioselectivities through the use of an electron-deficient phosphinooxazoline ligand, furnishing a highly congested and synthetically challenging stereocenter. The obtained alkylation products contain multiple reactive sites poised for additional functionalizations and diversification.

引用

页码：4272 / 4275

页数：4

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