Functional Magnetic Resonance Imaging Correlates of Emotional Word Encoding and Recognition in Depression and Anxiety Disorders

被引：89

作者：

van Tol, Marie-Jose ^{[1
,2
,3
]}

Demenescu, Liliana R. ^{[1
,4
]}

van der Wee, Nic J. A. ^{[2
,3
]}

Kortekaas, Rudle ^{[1
]}

Nielen, Marjan M. A. ^{[5
]}

Den Boer, J. A. ^{[6
]}

Renken, Remco J. ^{[1
]}

van Buchem, Mark A. ^{[3
,7
]}

Zitman, Frans G. ^{[2
]}

Aleman, Andre ^{[1
,8
]}

Veltman, Dick J. ^{[5
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Neuroimaging Ctr, NL-9713 AW Groningen, Netherlands

[2] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands

[3] Leiden Univ, Leiden Inst Brain & Cognit, Leiden, Netherlands

[4] Rhein Westfal TH Aachen, Dept Psychiat & Psychotherapy, Aachen, Germany

[5] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[6] Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands

[7] Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands

[8] Univ Groningen, Dept Psychol, NL-9713 AW Groningen, Netherlands

来源：

BIOLOGICAL PSYCHIATRY | 2012年 / 71卷 / 07期

关键词：

Emotional memory; fMRI; major depressive disorder; memory function; panic disorder; social anxiety disorder; GENERALIZED ANXIETY; ANTERIOR CINGULATE; MEMORY BIAS; ATTENTIONAL BIAS; BRAIN; ACTIVATION; AMYGDALA; MOOD; PERCEPTION; STIMULI;

D O I：

10.1016/j.biopsych.2011.11.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Major depressive disorder (MDD), panic disorder, and social anxiety disorder are among the most prevalent and frequently co-occurring psychiatric disorders in adults and may be characterized by a common deficiency in processing of emotional information. Methods: We used functional magnetic resonance imaging during the performance of an emotional word encoding and recognition paradigm in patients with MDD (n = 51), comorbid MDD and anxiety (n = 59), panic disorder and/or social anxiety disorder without comorbid MDD (n = 56), and control subjects (n = 49). In addition, we studied effects of illness severity, regional brain volume, and antidepressant use. Results: Patients with MDD, prevalent anxiety disorders, or both showed a common hyporesponse in the right hippocampus during positive (> neutral) word encoding compared with control subjects. During negative encoding, increased insular activation was observed in both depressed groups (MDD and MDD + anxiety), whereas increased amygdala and anterior cingulate cortex activation during positive word encoding were observed as depressive state-dependent effects in MDD only. During recognition, anxiety patients showed increased inferior frontal gyrus activation. Overall, effects were unaffected by medication use and regional brain volume. Conclusions: Hippocampal blunting during positive word encoding is a generic effect in depression and anxiety disorders, which may constitute a common vulnerability factor. Increased insular and amygdalar involvement during negative word encoding may underlie heightened experience of, and an inability to disengage from, negative emotions in depressive disorders. Our results emphasize a common neurobiological deficiency in both MDD and anxiety disorders, which may mark a general insensitiveness to positive information.

引用

页码：593 / 602

页数：10