Expression and distribution of endocan in human tissues

被引：122
作者：
Zhang, S. M. [1 ,2 ,3 ,6 ]
Zuo, L. [1 ,2 ,6 ]
Zhou, Q. [1 ,2 ,6 ]
Gui, S. Y. [4 ,6 ]
Shi, R. [1 ,2 ,6 ]
Wu, Q. [5 ]
Wei, W. [3 ,6 ]
Wang, Y. [1 ,2 ,3 ,6 ]
机构：
[1] Anhui Med Univ, Mol Biol Lab, Hefei 230032, Anhui, Peoples R China
[2] Anhui Med Univ, Dept Biochem, Hefei 230032, Anhui, Peoples R China
[3] Anhui Med Univ, Inst Clin Pharmacol, Hefei 230032, Anhui, Peoples R China
[4] Anhui Med Univ, Dept Resp Dis, Hefei 230032, Anhui, Peoples R China
[5] Anhui Med Univ, Dept Pathol, Hefei 230032, Anhui, Peoples R China
[6] Minist Educ & Anhui Prov, Key Lab Gene Resource Utilizat Severe Dis, Hefei, Anhui, Peoples R China
来源：
BIOTECHNIC & HISTOCHEMISTRY | 2012年 / 87卷 / 03期
基金：
中国国家自然科学基金;
关键词：
distribution; endocan; expression; human; CELL-SPECIFIC MOLECULE-1; HEPATOCELLULAR-CARCINOMA; ANGIOGENESIS; ESM-1; LUNG; SURVIVAL; CANCER; GENES;
D O I：
10.3109/10520295.2011.577754
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Endocan is a novel human endothelial cell specific molecule. Its expression is regulated by cytokines and vascular endothelial growth factor (VEGF). The distribution of endocan in normal human tissues, however, remains unclear. We examined the expression of endocan in normal human tissue using immunohistochemical stains. Endocan was expressed in actively proliferative or neogeneic tissues and cells such as glandular tissues, endothelium of neovasculature, bronchial epithelium, germinal centers of lymph nodes etc. Endocan was not present in silent or resting tissues or cells such as endothelium of great arteries and spleen etc. Our findings suggest that endocan may act as a marker for angiogenesis or oncogenesis and could be regarded as a candidate gene for inflammatory tissue, neoplasia, tumor development and metastasis. The expression level of endocan may assist early diagnosis and prognosis of some tumors.
引用
收藏
页码：172 / 178
页数：7
相关论文
共 20 条
  • [1] Identification of endothelial cell genes expressed in an in vitro model of angiogenesis:: Induction of ESM-1, βig-h3, and NrCAM
    Aitkenhead, M
    Wang, SJ
    Nakatsu, MN
    Mestas, J
    Heard, C
    Hughes, CCW
    [J]. MICROVASCULAR RESEARCH, 2002, 63 (02) : 159 - 171
  • [2] Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies
    Bechard, D
    Meignin, V
    Scherpereel, A
    Oudin, S
    Kervoaze, G
    Bertheau, P
    Janin, A
    Tonnel, AB
    Lassalle, P
    [J]. JOURNAL OF VASCULAR RESEARCH, 2000, 37 (05) : 417 - 425
  • [3] Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity
    Béchard, D
    Gentina, T
    Delehedde, M
    Scherpereel, A
    Lyon, M
    Aumercier, M
    Vazeux, R
    Richet, C
    Degand, P
    Jude, B
    Janin, A
    Fernig, DG
    Tonnel, AB
    Lassalle, P
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (51) : 48341 - 48349
  • [4] Human endothelial-cell specific molecule-1 binds directly to the integrin CD11a/CD18 (LFA-1) and blocks binding to intercellular adhesion molecule-1
    Béchard, D
    Scherpereel, A
    Hammad, H
    Gentina, T
    Tsicopoulos, A
    Aumercier, M
    Pestel, J
    Dessaint, JP
    Tonnel, AB
    Lassalle, P
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 167 (06) : 3099 - 3106
  • [5] Over-expression of the Endocan Gene in Endothelial Cells from Hepatocellular Carcinoma is Associated with Angiogenesis and Tumour Invasion
    Chen, L-Y
    Liu, X.
    Wang, S-L
    Qin, C-Y
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2010, 38 (02) : 498 - 510
  • [6] Endocan expression and relationship with survival in human non-small cell lung cancer
    Grigoriu, Bogdan Dragos
    Depontieu, Florence
    Scherpereel, Arnaud
    Gourcerol, Delphine
    Devos, Patrick
    Ouatas, Taoufik
    Lafitte, Jean-Jacques
    Copin, Marie-Christine
    Tonnel, Andre-Bernard
    Lassalle, Philippe
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (15) : 4575 - 4582
  • [7] Endocan Expression Correlated with Poor Survival in Human Hepatocellular Carcinoma
    Huang, Geng-Wen
    Tao, Yi-Ming
    Ding, Xiang
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2009, 54 (02) : 389 - 394
  • [8] Molecular origins of cancer: Tumor angiogenesis
    Kerbel, Robert S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (19) : 2039 - 2049
  • [9] Transforming growth factor-β-regulated gene transcription and protein expression in human GFAP-negative lamina cribrosa cells
    Kirwan, RP
    Leonard, MO
    Murphy, M
    Clark, AF
    O'Brien, CJ
    [J]. GLIA, 2005, 52 (04) : 309 - 324
  • [10] ESM-1 is a novel human endothelial cell-specific molecule expressed in lung and regulated by cytokines
    Lassalle, P
    Molet, S
    Janin, A
    VanderHeyden, J
    Tavernier, J
    Fiers, W
    Devos, R
    Tonnel, AB
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (34) : 20458 - 20464
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