Reliable measurements of brain atrophy in individual patients with multiple sclerosis

被引：57

作者：

Smeets, Dirk ^{[1
,2
]}

Ribbens, Annemie ^{[1
]}

Sima, Diana M. ^{[1
]}

Cambron, Melissa ^{[3
]}

Horakova, Dana ^{[4
,5
,6
]}

Jain, Saurabh ^{[1
]}

Maertens, Anke ^{[1
]}

Van Vlierberghe, Eline ^{[1
]}

Terzopoulos, Vasilis ^{[1
]}

Van Binst, Anne-Marie ^{[3
]}

Vaneckova, Manuela ^{[7
,8
]}

Krasensky, Jan ^{[7
,8
]}

Uher, Tomas ^{[4
,5
,6
]}

Seidl, Zdenek ^{[7
,8
]}

De Keyser, Jacques ^{[3
]}

Nagels, Guy ^{[9
]}

De Mey, Johan ^{[3
]}

Havrdova, Eva ^{[4
,5
,6
]}

Van Hecke, Wim ^{[1
]}

机构：

[1] Icometrix, R&D, Leuven, Belgium

[2] Univ Antwerp, BioImaging Lab, Antwerp, Belgium

[3] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Neurol, Ctr Neurosci, Brussels, Belgium

[4] Charles Univ Prague, Dept Neurol, Fac Med 1, Prague, Czech Republic

[5] Charles Univ Prague, Ctr Clin Neurosci, Fac Med 1, Prague, Czech Republic

[6] Gen Univ Hosp, Prague, Czech Republic

[7] Charles Univ Prague, Dept Radiol, Fac Med 1, Prague, Czech Republic

[8] Charles Univ Prague, Gen Univ Hosp, Prague, Czech Republic

[9] Natl Multiple Sclerosis Ctr, Melsbroek, Belgium

来源：

BRAIN AND BEHAVIOR | 2016年 / 6卷 / 09期

关键词：

brain atrophy; magnetic resonance images; MSmetrix; multiple sclerosis; PLACEBO-CONTROLLED TRIAL; GREY-MATTER ATROPHY; WHITE-MATTER; VOLUME CHANGES; JACOBIAN INTEGRATION; CEREBRAL ATROPHY; IMAGING OUTCOMES; MR-IMAGES; GRAY; ACCURATE;

D O I：

10.1002/brb3.518

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Introduction: As neurodegeneration is recognized as a major contributor to disability in multiple sclerosis (MS), brain atrophy quantification could have a high added value in clinical practice to assess treatment efficacy and disease progression, provided that it has a sufficiently low measurement error to draw meaningful conclusions for an individual patient. Method: In this paper, we present an automated longitudinal method based on Jacobian integration for measuring whole-brain and gray matter atrophy based on anatomical magnetic resonance images (MRI), named MSmetrix. MSmetrix is specifically designed to measure atrophy in patients with MS, by including iterative lesion segmentation and lesion filling based on FLAIR and T1-weighted MRI scans. Results: MSmetrix is compared with SIENA with respect to test-retest error and consistency, resulting in an average test-retest error on an MS data set of 0.13% (MSmetrix) and 0.17% (SIENA) and a consistency error of 0.07% (MSmetrix) and 0.05% (SIENA). On a healthy subject data set including physiological variability the test-retest is 0.19% (MSmetrix) and 0.31% (SIENA). Conclusion: Therefore, we can conclude that MSmetrix could be of added value in clinical practice for the follow-up of treatment and disease progression in MS patients.

引用

页数：12

共 67 条

[1] European validation of a standardized clinical description of multiple sclerosis [J].