Merkel Cell Carcinoma: A Virus-Induced Human Cancer

被引：150

作者：

Chang, Yuan ^{[1
,3
]}

Moore, Patrick S. ^{[2
,3
]}

机构：

[1] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Microbiol & Mol Genet, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Inst Canc, Canc Virol Program, Pittsburgh, PA 15213 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 | 2012年 / 7卷

关键词：

polyomavirus; primary cutaneous neuroendocrine cancer; large T antigen; small T antigen; digital transcriptome subtraction; NONMELANOMA SKIN-CANCER; AFRICAN-GREEN MONKEY; SMALL T-ANTIGENS; POLYOMAVIRUS INFECTION; NEUROENDOCRINE CARCINOMA; TRABECULAR CARCINOMA; KAPOSIS-SARCOMA; TUMOR-CELLS; DNA; SV40;

D O I：

10.1146/annurev-pathol-011110-130227

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Merkel cell polyomavirus (MCV) is the first polyomavirus directly linked to human cancer, and its recent discovery helps to explain many of the enigmatic features of Merkel cell carcinoma (MCC). MCV is clonally integrated into MCC tumor cells, which then require continued MCV oncoprotein expression to survive. The integrated viral genomes have a tumor-specific pattern of tumor antigen gene mutation that incapacitates viral DNA replication. This human cancer virus provides a new model in which a common, mostly harmless member of the human viral flora can initiate cancer if it acquires a precise set of mutations in a host with specific susceptibility factors, such as age and immune suppression. Identification of this tumor virus has led to new opportunities for early diagnosis and targeted treatment of MCC.

引用

页码：123 / 144

页数：22

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