Meta-Analysis Comparing Carvedilol Versus Metoprolol for the Prevention of Postoperative Atrial Fibrillation Following Coronary Artery Bypass Grafting

被引：39

作者：

DiNicolantonio, James J. ^{[1
]}

Beavers, Craig J. ^{[2
]}

Menezes, Arthur R. ^{[3
]}

Lavie, Carl J. ^{[3
,4
]}

O'Keefe, James H. ^{[5
]}

Meier, Pascal ^{[6
]}

Vorobcsuk, Andras ^{[7
]}

Aradi, Daniel ^{[7
,13
]}

Komocsi, Andras ^{[7
]}

Chatterjee, Saurav ^{[8
]}

D'Ascenzo, Fabrizio ^{[9
]}

Gasparini, Mauro ^{[10
]}

Brugts, Jasper ^{[11
]}

Biondi-Zoccai, Giuseppe ^{[12
]}

机构：

[1] Univ Missouri, Mid Amer Heart Inst, St Lukes Hosp, Dept Prevent Cardiol, Kansas City, MO 64110 USA

[2] Centennial Med Ctr, Dept Pharm, Nashville, TN USA

[3] Univ Queensland, Sch Med, Ochsner Clin Sch, John Ochsner Heart & Vasc Inst,Dept Cardiovasc Di, New Orleans, LA USA

[4] Pennington Biomed Res Ctr, Dept Prevent Med, Baton Rouge, LA 70808 USA

[5] Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA

[6] UCLH, Heart Hosp, London, England

[7] Univ Pecs, Ctr Heart, Dept Intervent Cardiol, Pecs, Hungary

[8] St Lukes Roosevelt Hosp, Div Cardiol, New York, NY USA

[9] Dept Internal Med, Div Cardiol, Turin, Italy

[10] Politecn Torino, Dept Math Sci, I-10129 Turin, Italy

[11] Erasmus MC Thoraxctr, Dept Cardiol, Rotterdam, Netherlands

[12] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Latina, Italy

[13] Ctr Heart, Dept Cardiol, Balatonfured, Hungary

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2014年 / 113卷 / 03期

关键词：

HEART-FAILURE; BETA-BLOCKER; DOUBLE-BLIND;

D O I：

10.1016/j.amjcard.2013.10.020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica (EMBASE) were searched up to March 2013 for suitable randomized controlled trials. Data were pooled using random-effects model for pairwise analyses. A total of 4 trials with 601 patients were included in this analysis. Pairwise analyses showed that compared with metoprolol, carvedilol significantly reduced the incidence of postoperative atrial fibrillation (odds ratio 0.50, 95% confidence interval 0.32 to 0.80). In conclusion, compared with metoprolol, carvedilol significantly reduces the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：565 / 569

页数：5

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