Association of HLA locus variant in Parkinson's disease

被引：19

作者：

Zhao, Y. ^{[1
,2
]}

Gopalai, A. A. ^{[3
]}

Ahmad-Annuar, A. ^{[3
]}

Teng, E. W. L. ^{[1
,2
]}

Prakash, K. M. ^{[1
,2
]}

Tan, L. C. S. ^{[1
,2
]}

Au, W-L ^{[1
,2
]}

Li, H-H ^{[1
,2
]}

Lim, S-Y ^{[4
]}

Lim, S. K. ^{[4
]}

Chong, Y. B. ^{[4
]}

Tan, L. P. ^{[4
]}

Ibrahim, N. M. ^{[5
]}

Tan, E-K ^{[1
,2
,6
]}

机构：

[1] Singapore Gen Hosp, Dept Neurol, Natl Neurosci Inst, Singapore 169608, Singapore

[2] Singapore Gen Hosp, Dept Clin Res, Natl Neurosci Inst, Singapore 169608, Singapore

[3] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur, Malaysia

[4] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur, Malaysia

[5] Univ Kebangsaan Malaysia, Dept Med, Bangi 43600, Malaysia

[6] Duke NUS Grad Med Sch, Singapore, Singapore

来源：

CLINICAL GENETICS | 2013年 / 84卷 / 05期

基金：

英国医学研究理事会;

关键词：

Chinese; gene; Parkinson's disease; polymorphism; REGION; REPLICATION; SNCA; MAPT;

D O I：

10.1111/cge.12024

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A variant (rs3129882) in the genome-wide association study (GWAS)-linked variant [in the human leukocyte antigen (HLA) gene region] has been reported to associate with an increased risk of Parkinson's disease (PD) in Caucasian population. Studies among Chinese are limited. To address this, we analysed rs3129882 in a total of 1312 subjects of Chinese ethnicity from independent Asian centers comprising of 675 controls and 637 PD cases. The rs3129882 variant was associated with a decreased risk in our ethnic Chinese PD patients. Logistic regression analysis taking into consideration variables of age, gender and race showed that allele A reduced the risk of PD via a dominant model [odds ratio (OR)=0.77, 95% confidence interval (CI)=0.62, 0.96, p=0.018]. As HLA is a highly polymorphic region, it is possible that ethnic-specific effect or environmental agents may modulate the effect of this GWAS-linked locus in influencing the risk of PD.

引用

页码：501 / 504

页数：4

共 8 条

[1] Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease [J].

Chiang, Han-Lin ;

Lee-Chen, Guey-Jen ;

Chen, Chiung Mei ;

Chen, Yi-Chun ;

Lee, Chei-Mei ;

Liao, Ming-Hui ;

Wu, Yih-Ru .

PARKINSONISM & RELATED DISORDERS, 2012, 18 (04) :391-393

[2] Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease [J].

Edwards, Todd L. ;

Scott, William K. ;

Almonte, Cherylyn ;

Burt, Amber ;

Powell, Eric H. ;

Beecham, Gary W. ;

Wang, Liyong ;

Zuchner, Stephan ;

Konidari, Ioanna ;

Wang, Gaofeng ;

Singer, Carlos ;

Nahab, Fatta ;

Scott, Burton ;

Stajich, Jeffrey M. ;

Pericak-Vance, Margaret ;

Haines, Jonathan ;

Vance, Jeffery M. ;

Martin, Eden R. .

ANNALS OF HUMAN GENETICS, 2010, 74 :97-109

[3] HLA rs3129882 variant in Chinese Han patients with late-onset sporadic Parkinson disease [J].

Guo, Yi ;

Deng, Xiong ;

Zheng, Wen ;

Xu, Hongbo ;

Song, Zhi ;

Liang, Hui ;

Lei, Jin ;

Jiang, Xuhong ;

Luo, Ziqiang ;

Deng, Hao .

NEUROSCIENCE LETTERS, 2011, 501 (03) :185-187

[4] Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease [J].

Hamza, Taye H. ;

Zabetian, Cyrus P. ;

Tenesa, Albert ;

Laederach, Alain ;

Montimurro, Jennifer ;

Yearout, Dora ;

Kay, Denise M. ;

Doheny, Kimberly F. ;

Paschall, Justin ;

Pugh, Elizabeth ;

Kusel, Victoria I. ;

Collura, Randall ;

Roberts, John ;

Griffith, Alida ;

Samii, Ali ;

Scott, William K. ;

Nutt, John ;

Factor, Stewart A. ;

Payami, Haydeh .

NATURE GENETICS, 2010, 42 (09) :781-U75

[5] Replication of MAPT and SNCA, but not PARK16-18, as Susceptibility Genes for Parkinson's Disease [J].

Mata, Ignacio F. ;

Yearout, Dora ;

Alvarez, Victoria ;

Coto, Eliecer ;

de Mena, Lorena ;

Ribacoba, Renee ;

Lorenzo-Betancor, Oswaldo ;

Samaranch, Lluis ;

Pastor, Pau ;

Cervantes, Sebastian ;

Infante, Jon ;

Garcia-Gorostiaga, Ines ;

Sierra, Maria ;

Combarros, Onofre ;

Snapinn, Katherine W. ;

Edwards, Karen L. ;

Zabetian, Cyrus P. .

MOVEMENT DISORDERS, 2011, 26 (05) :819-823

[6] Large-scale replication and heterogeneity in Parkinson disease genetic loci [J].

Sharma, Manu ;

Ioannidis, John P. A. ;

Aasly, Jan O. ;

Annesi, Grazia ;

Brice, Alexis ;

Van Broeckhoven, Christine ;

Bertram, Lars ;

Bozi, Maria ;

Crosiers, David ;

Clarke, Carl ;

Facheris, Maurizio ;

Farrer, Matthew ;

Garraux, Gaetan ;

Gispert, Suzana ;

Auburger, Georg ;

Vilarino-Gueell, Carles ;

Hadjigeorgiou, Georgios M. ;

Hicks, Andrew A. ;

Hattori, Nobutaka ;

Jeon, Beom ;

Lesage, Suzanne ;

Lill, Christina M. ;

Lin, Juei-Jueng ;

Lynch, Timothy ;

Lichtner, Peter ;

Lang, Anthony E. ;

Mok, Vincent ;

Jasinska-Myga, Barbara ;

Mellick, George D. ;

Morrison, Karen E. ;

Opala, Grzegorz ;

Pramstaller, Peter P. ;

Pichler, Irene ;

Park, Sung Sup ;

Quattrone, Aldo ;

Rogaeva, Ekaterina ;

Ross, Owen A. ;

Stefanis, Leonidas ;

Stockton, Joanne D. ;

Satake, Wataru ;

Silburn, Peter A. ;

Theuns, Jessie ;

Tan, Eng-King ;

Toda, Tatsushi ;

Tomiyama, Hiroyuki ;

Uitti, Ryan J. ;

Wirdefeldt, Karin ;

Wszolek, Zbigniew ;

Xiromerisiou, Georgia ;

Yueh, Kuo-Chu .

NEUROLOGY, 2012, 79 (07) :659-667

[7] Genome-wide association study confirms extant PD risk loci among the Dutch [J].

Simon-Sanchez, Javier ;

van Hilten, Jacobus J. ;

van de Warrenburg, Bart ;

Post, Bart ;

Berendse, Henk W. ;

Arepalli, Sampath ;

Hernandez, Dena G. ;

de Bie, Rob M. A. ;

Velseboer, Daan ;

Scheffer, Hans ;

Bloem, Bas ;

van Dijk, Karin D. ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Rizzu, Patrizia ;

Bochdanovits, Zoltan ;

Singleton, Andrew B. ;

Heutink, Peter .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2011, 19 (06) :655-661

[8] Pathogenic mutations in Parkinson disease [J].

Tan, Eng-King ;

Skipper, Lisa M. .

HUMAN MUTATION, 2007, 28 (07) :641-653

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