The Hair Follicle: An Underutilized Source of Cells and Materials for Regenerative Medicine

被引:33
作者
Kiani, Mehrdad T. [1 ,2 ]
Higgins, Claire A. [1 ]
Almquist, Benjamin D. [1 ]
机构
[1] Imperial Coll London, Royal Sch Mines, Dept Bioengn, London SW7 2AZ, England
[2] Stanford Univ, Dept Mat Sci, 496 Lomita Mall, Stanford, CA 94305 USA
来源
ACS BIOMATERIALS SCIENCE & ENGINEERING | 2018年 / 4卷 / 04期
基金
英国惠康基金; 英国医学研究理事会;
关键词
hair follicle; keratin; wound healing; biomaterials; regenerative medicine; stem cells; DERMAL PAPILLA CELLS; OCULAR SURFACE RECONSTRUCTION; KERATIN HYDROGELS SUPPORT; IN-VITRO CHARACTERIZATION; SCIATIC-NERVE INJURY; FUNCTIONAL BODY HAIR; ARRECTOR PILI MUSCLE; ROOT SHEATH-CELLS; STEM-CELL; BIOLOGICAL EVALUATION;
D O I
10.1021/acsbiomaterials.7b00072
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The hair follicle is one of only two structures within the adult body that selectively degenerates and regenerates, making it an intriguing organ to study and use for regenerative medicine. Hair follicles have been shown to influence wound healing, angiogenesis, neurogenesis, and harbor distinct populations of stem cells; this has led to cells from the follicle being used in clinical trials for tendinosis and chronic ulcers. In addition, keratin produced by the follicle in the form of a hair fiber provides an abundant source of biomaterials for regenerative medicine. In this review, we provide an overview of the structure of a hair follicle, explain the role of the follicle in regulating the microenvironment of skin and the impact on wound healing, explore individual cell types of interest for regenerative medicine, and cover several applications of keratin-based biomaterials.
引用
收藏
页码:1193 / 1207
页数:29
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