Cancer chemopreventive diterpenes from Salvia corrugata

被引：25
作者：
Giacomelli, Emanuela [1 ]
Bertrand, Samuel [2 ]
Nievergelt, Andreas [2 ]
Zwick, Vincent [2 ]
Simoes-Pires, Claudia [2 ]
Marcourt, Laurence [2 ]
Rivara-Minten, Elisabeth [2 ]
Cuendet, Muriel [2 ]
Bisio, Angela [1 ]
Wolfender, Jean-Luc [2 ]
机构：
[1] Univ Genoa, Dept Pharm, I-16147 Genoa, Italy
[2] Univ Geneva, Sch Pharmaceut Sci, CH-1211 Geneva 4, Switzerland
来源：
PHYTOCHEMISTRY | 2013年 / 96卷
关键词：
Salvia corrugata; Diterpenes; Abietane; Icetexane; Fruticulin C; Quinone reductase; Histone deacetylase; REDUCTASE-INDUCING ACTIVITY; MORINDA-CITRIFOLIA NONI; QUINONE REDUCTASE; ABIETANE DITERPENOIDS; ICETEXANE DITERPENOIDS; DEMETHYL FRUTICULIN; INDUCTION; CHROMATOGRAPHY; CONSTITUENTS; GILLIESSI;
D O I：
10.1016/j.phytochem.2013.09.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by alpha-hydroxy-beta-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7 alpha-methoxy-19-acetoxy-royleanone (4), 7 alpha,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7 alpha-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：257 / 264
页数：8
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