Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway

被引：11
|
作者：
Li, Jia [1 ,2 ]
Peng, Jiangtong [1 ,2 ]
Zhao, Shengnan [1 ,3 ]
Zhong, Yi [1 ,2 ]
Wang, Yilong [1 ,2 ]
Hu, Ji [1 ,2 ]
Zhang, Chao [4 ]
Cheng, Min [1 ,2 ]
Xia, Geqing [5 ]
Hu, Yu [6 ]
Huang, Kai [1 ,2 ]
Wang, Yan [1 ,2 ]
Liang, Minglu [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Genom Res, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Pathol, Tongii Hosp, Wuhan, Hubei, Peoples R China
[5] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
基金：
中国国家自然科学基金;
关键词：
angiogenesis; TUSSILAGONE; VEGFR2 signaling pathway; human umbilical vascular endothelial cell; vascular endothelial growth factor; CELL FUNCTIONS;
D O I：
10.3389/fphar.2019.00764
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer feature that is essential for supplying oxygen and nutrients to all proliferating tumor cells. Here, we demonstrated that TSL significantly inhibited the proliferation, migration, invasion, and tube formation of primary human umbilical vascular endothelial cell (HUVEC) in vitro. Also, TSL inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis revealed by Matrigel plug assay in vivo. At present, we observed that TSL inhibited the activity of VEGFR2 signal pathway induced by VEGF. These findings suggested that TSL may serve as a potential therapeutic target in the angiogenesis.
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页数：11
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