Tussilagone Suppresses Angiogenesis by Inhibiting the VEGFR2 Signaling Pathway

被引：11
|
作者：
Li, Jia [1 ,2 ]
Peng, Jiangtong [1 ,2 ]
Zhao, Shengnan [1 ,3 ]
Zhong, Yi [1 ,2 ]
Wang, Yilong [1 ,2 ]
Hu, Ji [1 ,2 ]
Zhang, Chao [4 ]
Cheng, Min [1 ,2 ]
Xia, Geqing [5 ]
Hu, Yu [6 ]
Huang, Kai [1 ,2 ]
Wang, Yan [1 ,2 ]
Liang, Minglu [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Genom Res, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan, Hubei, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Pathol, Tongii Hosp, Wuhan, Hubei, Peoples R China
[5] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China
[6] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
基金：
中国国家自然科学基金;
关键词：
angiogenesis; TUSSILAGONE; VEGFR2 signaling pathway; human umbilical vascular endothelial cell; vascular endothelial growth factor; CELL FUNCTIONS;
D O I：
10.3389/fphar.2019.00764
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tussilagone (TSL) is a sesquiterpenoid isolated from Tussilago farfara, which has been used as a traditional medicine for the treatment of asthma and bronchitis. It also takes part in the anti-inflammatory and antioxidant effects, but its role in angiogenesis is unknown. Angiogenesis is a cancer feature that is essential for supplying oxygen and nutrients to all proliferating tumor cells. Here, we demonstrated that TSL significantly inhibited the proliferation, migration, invasion, and tube formation of primary human umbilical vascular endothelial cell (HUVEC) in vitro. Also, TSL inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis revealed by Matrigel plug assay in vivo. At present, we observed that TSL inhibited the activity of VEGFR2 signal pathway induced by VEGF. These findings suggested that TSL may serve as a potential therapeutic target in the angiogenesis.
引用
收藏
页数：11
相关论文
共 50 条
  • [21] CS2164 suppresses acute myeloid leukemia cell growth via inhibiting VEGFR2 signaling in preclinical models
    Deng, Manman
    Zhao, Haijun
    Chen, Qinwei
    Zhao, Jintao
    Shi, Yuanfei
    Yu, Lian
    Fang, Zhihong
    Xu, Bing
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 853 : 193 - 200
  • [22] Polyene phosphatidylcholine promotes tibial fracture healing in rats by stimulating angiogenesis dominated by the VEGFA/VEGFR2 signaling pathway
    Chen, Xing
    Du, Jinge
    Zhan, Wenxuan
    Shao, Binghao
    Jiang, Huaying
    Chen, Zhaolong
    Wang, Chunmei
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 719
  • [23] MiR-203 Participates in Human Placental Angiogenesis by Inhibiting VEGFA and VEGFR2 Expression
    Liu, Fulin
    Wu, Wanrong
    Wu, Kejia
    Chen, Yurou
    Wu, Hanshu
    Wang, Hui
    Zhang, Wei
    REPRODUCTIVE SCIENCES, 2018, 25 (03) : 358 - 365
  • [24] Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway
    Zhang, Pan
    Lai, Xing
    Zhu, Mao-Hua
    Long, Mei
    Liu, Xue-Liang
    Wang, Zi-Xiang
    Zhang, Yifan
    Guo, Run-Jie
    Dong, Jing
    Lu, Qin
    Sun, Peng
    Fang, Chao
    Zhao, Mei
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [25] Rutacecarpine Inhibits Angiogenesis by Targeting the VEGFR2 and VEGFR2-Mediated Akt/mTOR/p70s6k Signaling Pathway
    Ji, Lijun
    Wu, Mingfei
    Li, Zeng
    MOLECULES, 2018, 23 (08)
  • [26] MiR-203 Participates in Human Placental Angiogenesis by Inhibiting VEGFA and VEGFR2 Expression
    Fulin Liu
    Wanrong Wu
    Kejia Wu
    Yurou Chen
    Hanshu Wu
    Hui Wang
    Wei Zhang
    Reproductive Sciences, 2018, 25 : 358 - 365
  • [27] Brucine, an indole alkaloid from Strychnos nux-vomica attenuates VEGF-induced angiogenesis via inhibiting VEGFR2 signaling pathway in vitro and in vivo
    Saraswati, Sarita
    Agrawal, S. S.
    CANCER LETTERS, 2013, 332 (01) : 83 - 93
  • [28] Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis Glycans make the difference
    Croci, Diego O.
    Rabinovich, Gabriel A.
    ONCOIMMUNOLOGY, 2014, 3 (06)
  • [29] Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling
    Wang, Zheng
    Jin, Can
    Li, Xueying
    Ding, Kan
    CARBOHYDRATE POLYMERS, 2019, 207 : 502 - 509
  • [30] Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis
    Somanath, Payaningal R.
    Malinin, Nikolay L.
    Byzova, Tatiana V.
    ANGIOGENESIS, 2009, 12 (02) : 177 - 185
12345