Mechanisms of lymphatic metastasis

被引：471

作者：

Karaman, Sinem ^{[1
]}

Detmar, Michael ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Pharmaceut Sci, CH-8093 Zurich, Switzerland

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 03期

基金：

欧洲研究理事会;

关键词：

HEPATOCYTE GROWTH-FACTOR; TUMOR-CELL ENTRY; NODE LYMPHANGIOGENESIS; VEGF-C; MOLECULAR-MECHANISMS; ENDOTHELIAL-CELLS; INTRATUMORAL LYMPHANGIOGENESIS; MELANOMA METASTASIS; CUTANEOUS MELANOMA; PROGENITOR CELLS;

D O I：

10.1172/JCI71606

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Malignant tumors release growth factors such as VEGF-C to induce lymphatic vessel expansion (lymphangiogenesis) in primary tumors and in draining sentinel LNs, thereby promoting LN metastasis. Surprising recent evidence suggests that lymphatic vessels do not merely represent passive channels for tumor spread, but that they may actively promote tumor cell recruitment to LNs, cancer stem cell survival, and immune modulation. New imaging approaches allow the sensitive visualization of the earliest LN metastases and the quantitative, noninvasive measurement of the function of tumor-draining lymphatic vessels, with potential applications in the development of biomarkers for prognosis and measurement of therapeutic response.

引用

页码：922 / 928

页数：7

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