CDH1 C-160A promoter polymorphism and gastric cancer risk

被引：17

作者：

Corso, Giovanni ^{[1
]}

Berardi, Anna ^{[1
]}

Marrelli, Daniele ^{[1
]}

Pedrazzani, Corrado ^{[1
]}

Garosi, Lorenzo ^{[1
]}

Pinto, Enrico ^{[1
]}

Roviello, Franco ^{[1
]}

机构：

[1] Univ Siena, Dept Human Pathol & Oncol, Unit Surg Oncol, Translat Res Lab,ITT, I-53100 Siena, Italy

来源：

EUROPEAN JOURNAL OF CANCER PREVENTION | 2009年 / 18卷 / 01期

关键词：

E-cadherin; gastric cancer; single nucleotide polymorphism; E-CADHERIN GENE; SINGLE NUCLEOTIDE POLYMORPHISM; FAMILY-HISTORY; STOMACH-CANCER; POPULATION; CARCINOMA; ASSOCIATION; MUTATIONS; TUSCANY;

D O I：

10.1097/CEJ.0b013e32830c8d70

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study was to find out whether C-160A single nucleotide polymorphism of the promoter region of the E-cadherin gene might be a potential genetic marker for identifying individuals at risk for gastric cancer (GC). To test this hypothesis, 412 GC patients and 408 controls were analyzed statistically. A PCR-restriction fragment length polymorphism assay was adopted for C-160A single nucleotide polymorphism detection. No statistical differences were found among CC, CA, and AA genotypes and the risk of GC, even stratifying according to age, sex, and area of residence. Similarly, genotype was not associated with intestinal or diffuse histotypes, or with cardia or noncardia carcinomas. In conclusion, the C-160A polymorphism is not associated with GC risk in the Italian population. European Journal of Cancer Prevention 18:46-49 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：46 / 49

页数：4

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