Pulmonary miliary tuberculosis in a patient with anti-TNF-alpha treatment

被引：60
作者：
Mayordomo, L
Marenco, JL
Gomez-Mateos, J
Rejon, E
机构：
[1] Hosp Univ Valme, Rheumatol Unit, Seville, Spain
[2] Hosp Univ Valme, Infect Dis Unit, Seville, Spain
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2002年 / 31卷 / 01期
关键词：
infliximab; anti-TNF-alpha; miliary tuberculosis; rheumatoid arthritis; inflammatory bowel disease;
D O I：
10.1080/030097402317255372
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
No difference in the number of serious adverse events was reported in previous clinical trials in rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) patients treated with TNF-alpha blockade, but a patient died because of disseminated tuberculosis. A tuberculosis reactivation in a patient with IBD and anti-TNF-alpha treatment has been recently reported. Very recently 70 cases of tuberculosis were reported from the FDA Adverse Event Reporting System. We report it case of pulmonary miliary tuberculosis in a RA patient treated with TNF-alpha blockade. The important role of TNF-alpha in defence against tuberculosis and possible mechanisms of anti-TNF-alpha agents impairing tuberculosis immune response are discussed.
引用
收藏
页码：44 / 45
页数：2
相关论文
共 19 条
[1]  
Bopst M, 2001, EUR J IMMUNOL, V31, P1935, DOI 10.1002/1521-4141(200106)31:6&lt
[2]  
1935::AID-IMMU1935&gt
[3]  
3.0.CO
[4]  
2-N
[5]   Mechanisms of disease: Cytokine pathways and joint inflammation in rheumatoid arthritis. [J].
Choy, EHS ;
Panayi, GS .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (12) :907-916
[6]   Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12 [J].
Ehlers, S ;
Kutsch, S ;
Ehlers, EM ;
Benini, J ;
Pfeffer, K .
JOURNAL OF IMMUNOLOGY, 2000, 165 (01) :483-492
[7]   Anti-tumor necrosis factor-alpha therapy of rheumatoid arthritis [J].
Feldmann, M ;
Elliott, MJ ;
Woody, JN ;
Maini, RN .
ADVANCES IN IMMUNOLOGY, VOL 64, 1997, 64 :283-350
[8]   High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections:: synergistic action of TNF and IFN-γ in the differentiation of protective granulomas [J].
Garcia, I ;
Miyazaki, Y ;
Marchal, G ;
Lesslauer, W ;
Vassalli, P .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (12) :3182-3190
[9]   THE TRANSMEMBRANE FORM OF TUMOR-NECROSIS-FACTOR IS THE PRIME ACTIVATING LIGAND OF THE 80 KDA TUMOR-NECROSIS-FACTOR RECEPTOR [J].
GRELL, M ;
DOUNI, E ;
WAJANT, H ;
LOHDEN, M ;
CLAUSS, M ;
MAXEINER, B ;
GEORGOPOULOS, S ;
LESSLAUER, W ;
KOLLIAS, G ;
PFIZENMAIER, K ;
SCHEURICH, P .
CELL, 1995, 83 (05) :793-802
[10]   Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity [J].
Jacobs, M ;
Brown, N ;
Allie, N ;
Chetty, K ;
Ryffel, B .
PATHOBIOLOGY, 2000, 68 (02) :68-75
12