Ghrelin fluctuation, what determines its production?

被引：48

作者：

Yin, Xuefeng ^{[1
]}

Li, Yin ^{[1
]}

Xu, Geyang ^{[1
]}

An, Wenjiao ^{[1
]}

Zhang, Weizhen ^{[1
,2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

[2] Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2009年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ghrelin; regulation; diet; secretion; biosynthesis; INSULIN-INDUCED HYPOGLYCEMIA; SERUM ACYLATED GHRELIN; ESSENTIAL AMINO-ACIDS; ORAL GLUCOSE-LOAD; BODY-MASS INDEX; GROWTH-FACTOR-I; CIRCULATING GHRELIN; PLASMA GHRELIN; FOOD-INTAKE; HIGH-FAT;

D O I：

10.1093/abbs/gmp001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.

引用

页码：188 / 197

页数：10

共 110 条

[71] A role for ghrelin in the central regulation of feeding [J].

Nakazato, M ;

Murakami, N ;

Date, Y ;

Kojima, M ;

Matsuo, H ;

Kangawa, K ;

Matsukura, S .

NATURE, 2001, 409 (6817) :194-198

[72] Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern [J].

Natalucci, G ;

Riedl, S ;

Gleiss, A ;

Zidek, T ;

Frisch, H .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 152 (06) :845-850

[73] Developmental changes in the pattern of ghrelin's acyl modification and the levels of acyl-modified ghrelins in murine stomach [J].

Nishi, Y ;

Hiejima, H ;

Mifune, H ;

Sato, T ;

Kangawa, K ;

Kojima, M .

ENDOCRINOLOGY, 2005, 146 (06) :2709-2715

[74] Ingested medium-chain fatty acids are directly utilized for the acyl modification of ghrelin [J].

Nishi, Y ;

Hiejima, H ;

Hosoda, H ;

Kaiya, H ;

Mori, K ;

Fukue, Y ;

Yanase, T ;

Nawata, H ;

Kangawa, K ;

Kojima, M .

ENDOCRINOLOGY, 2005, 146 (05) :2255-2264

[75] Improving reproductive performance in overweight/obese women with effective weight management [J].

Norman, RJ ;

Noakes, M ;

Wu, RJ ;

Davies, MJ ;

Moran, L ;

Wang, JX .

HUMAN REPRODUCTION UPDATE, 2004, 10 (03) :267-280

[76]

Otto B, 2001, EUR J ENDOCRINOL, V145, pR5

[77] Role of the duodenum and macronutrient type in ghrelin regulation [J].

Overduin, J ;

Frayo, RS ;

Grill, HJ ;

Kaplan, JM ;

Cummings, DE .

ENDOCRINOLOGY, 2005, 146 (02) :845-850

[78] Production of bioactive peptides in an in vitro system [J].

Ozawa, Akihiko ;

Cai, Yang ;

Lindberg, Iris .

ANALYTICAL BIOCHEMISTRY, 2007, 366 (02) :182-189

[79] Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children [J].

Pacifico, Lucia ;

Anania, Caterina ;

Osborn, John F. ;

Ferrara, Eva ;

Schiavo, Elisa ;

Bonamico, Margherita ;

Chiesa, Claudio .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2008, 158 (03) :323-332

[80] Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men [J].

Poppitt, SD ;

Leahy, E ;

Keogh, GF ;

Wang, Y ;

Mulvey, TB ;

Stojkovic, M ;

Chan, YK ;

Choong, YS ;

McArdle, BH ;

Cooper, GJS .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2006, 60 (01) :77-84

← 2 3 4 5 6 7 8 9 10 11 →