Ghrelin fluctuation, what determines its production?

被引：48

作者：

Yin, Xuefeng ^{[1
]}

Li, Yin ^{[1
]}

Xu, Geyang ^{[1
]}

An, Wenjiao ^{[1
]}

Zhang, Weizhen ^{[1
,2
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100191, Peoples R China

[2] Univ Michigan, Med Ctr, Dept Surg, Ann Arbor, MI 48109 USA

来源：

ACTA BIOCHIMICA ET BIOPHYSICA SINICA | 2009年 / 41卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ghrelin; regulation; diet; secretion; biosynthesis; INSULIN-INDUCED HYPOGLYCEMIA; SERUM ACYLATED GHRELIN; ESSENTIAL AMINO-ACIDS; ORAL GLUCOSE-LOAD; BODY-MASS INDEX; GROWTH-FACTOR-I; CIRCULATING GHRELIN; PLASMA GHRELIN; FOOD-INTAKE; HIGH-FAT;

D O I：

10.1093/abbs/gmp001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ghrelin, a 28 amino acid gut brain peptide, acts as an endogenous ligand for its receptor, the growth hormone secretagogue receptor, to exercise a variety of functions ranging from stimulation of growth hormone secretion, regulation of appetite and energy metabolism, and cell protection to modulation of inflammation. This review summarizes the advance in the regulation of ghrelin expression and secretion. We introduce the structure of ghrelin promoter, the processing and modification of ghrelin precursor, and the regulation mechanism in these processes. Then we discuss factors found to be important in the regulation of ghrelin production, including nutrients, hormones, and autonomic nervous system. Finally, we outline the alteration in the level of ghrelin in certain physiological and pathological status.

引用

页码：188 / 197

页数：10

共 110 条

[51] Estrogen replacement therapy increases plasma ghrelin levels [J].

Kellokoski, E ;

Pöykkö, SM ;

Karjalainen, AH ;

Ukkola, O ;

Heikkinen, J ;

Kesäniemi, YA ;

Hörkkö, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (05) :2954-2963

[52] Not insulin but insulin sensivity, leptin, and cortisol are major factors regulating serum acylated ghrelin level in healthy women [J].

Kempa, A. ;

Krzyzanowska-Swiniarska, B. ;

Miazgowski, T. ;

Pilarska, K. .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 2007, 30 (08) :659-665

[53] Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans [J].

Kim, Sang Wan ;

Kim, Kyung Won ;

Shin, Chan Soo ;

Park, Do Joon ;

Park, Kyong Soo ;

Cho, Bo Youn ;

Lee, Hong Kyu ;

Kim, Seong Yeon .

HORMONE RESEARCH, 2007, 67 (05) :211-219

[54] Endocrine effects of food intake:: Insulin, ghrelin, and leptin responses to a single bolus of essential amino acids in humans [J].

Knerr, I ;

Gröschl, M ;

Rascher, W ;

Rauh, M .

ANNALS OF NUTRITION AND METABOLISM, 2003, 47 (06) :312-318

[55] Ghrelin is a growth-hormone-releasing acylated peptide from stomach [J].

Kojima, M ;

Hosoda, H ;

Date, Y ;

Nakazato, M ;

Matsuo, H ;

Kangawa, K .

NATURE, 1999, 402 (6762) :656-660

[56] Ghrelin: Structure and function [J].

Kojima, M ;

Kangawa, K .

PHYSIOLOGICAL REVIEWS, 2005, 85 (02) :495-522

[57]

Kozakowski J, 2008, NEUROENDOCRINOL LETT, V29, P100

[58] Serum acylated ghrelin, adiponectin and leptin levels in normal-weight and obese premenopausal women [J].

Krzyanowska-Swinlarska, B. ;

Kempa, A. ;

Miazgowski, T. ;

Pilarska, K. .

HORMONE AND METABOLIC RESEARCH, 2007, 39 (11) :835-839

[59] Circulating leptin and ghrelin are differentially influenced by estrogen/progestin therapy and raloxifene [J].

Lambrinoudaki, Irene V. ;

Christodoulakos, George E. ;

Economou, Emmanuel V. ;

Vlachou, Sofia A. ;

Panoulis, Constantinos P. ;

Alexandrou, Andreas P. ;

Kouskouni, Evangelia E. ;

Creatsas, George C. .

MATURITAS, 2008, 59 (01) :62-71

[60]

Lejeune MPGM, 2006, AM J CLIN NUTR, V83, P89

← 1 2 3 4 5 6 7 8 9 10 →