Cathelicidins: microbicidal activity, mechanisms of action, and roles in innate immunity

被引：234

作者：

Ramanathan, B ^{[1
]}

Davis, EG ^{[1
]}

Ross, CR ^{[1
]}

Blecha, F ^{[1
]}

机构：

[1] Kansas State Univ, Coll Vet Med, Dept Anat & Physiol, Manhattan, KS 66506 USA

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 03期

基金：

美国农业部;

关键词：

cathelicidin; antimicrobial peptides; innate immunity; natural antibiotics;

D O I：

10.1016/S1286-4579(02)01549-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimicrobial peptides are important host-defense molecules of innate immunity. Cathelicidins are a diverse family of potent, rapidly acting and broadly effective antimicrobial peptides, which are produced by a variety of cells. This review examines the classification, antimicrobial spectrum, mechanism of action, and regulation of cathelicidins. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：361 / 372

页数：12

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