Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours
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作者:
Yim, Hyeona
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Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South KoreaCatholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea
Yim, Hyeona
[1
]
Park, Sin-jung
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Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South KoreaCatholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea
Park, Sin-jung
[1
]
Bae, You Han
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USACatholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea
Bae, You Han
[2
]
Na, Kun
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Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South KoreaCatholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea
Na, Kun
[1
]
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[1] Catholic Univ Korea, Dept Biotechnol, Bucheon Si 420743, Gyeonggi Do, South Korea
[2] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA
To enhance limited drug penetration that mediated drug resistance and heterogeneity within the tumour microenvironment, we designed a paclitaxel (PTX) loaded degradable cationic nanogel (DpNG) consisted with acetylated pullulan and low molecular weight polyethyleneimine ((Low)bPEI, 1.8 kDa). The restoration of cationic charge on the DpNG was achieved via HA degradation by hyaluronidase which is secreted in tumour. The size and surface charge of HA-coated DpNG loaded with PTX (HA/DpNG-PTX) was 200-250 nm and 0 my, respectively. The DpNG-PTX was showed significant cytotoxicity in heterogeneous cancer cells. The IC50 value of DpNG-PTX was 100 times less than that of free PTX. The growth of heterogeneous tumour in Balb/c mice was inhibited via intravenous injection of HA/DpNG-PTX. Furthermore, the invasive distance and amount of HA/DpNG-PTX localised within the deep tissue regions were increased two times than that of PA-PTX. Therefore, the DpNG based drug delivery system could be useful for treatment of heterogeneous tumour. (C) 2013 Elsevier Ltd. All rights reserved.
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA
Denison, Tracy A.
Bae, You Han
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA
Utah Inha Drug Delivery Syst & Adv Therapeut Res, Songdo, Incheon, South KoreaUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA
机构:
Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USAUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA
Denison, Tracy A.
Bae, You Han
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Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA
Utah Inha Drug Delivery Syst & Adv Therapeut Res, Songdo, Incheon, South KoreaUniv Utah, Dept Pharmaceut & Pharmaceut Chem, Coll Pharm, Salt Lake City, UT 84108 USA