COVID-19 was not associated or trigger disease activity in spondylarthritis patients: ReumaCoV-Brasil cross-sectional data

被引：3

作者：

Lopes Marques, Claudia Diniz ^{[1
]}

Ribeiro, Sandra Lucia Euzebio ^{[2
]}

Albuquerque, Cleandro P. ^{[3
]}

de Sousa Studart, Samia Araujo ^{[4
]}

Ranzolin, Aline ^{[5
]}

Bueno de Andrade, Nicole Pamplona ^{[6
]}

Dantas, Andrea T. ^{[1
]}

Mota, Guilherme D. ^{[7
]}

Resende, Gustavo G. ^{[8
]}

Marinho, Adriana O. ^{[9
]}

Angelieri, Danielle ^{[10
]}

Andrade, Danieli ^{[11
]}

Ribeiro, Francinne M. ^{[12
]}

Omura, Felipe ^{[13
]}

Silva, Nilzio A. ^{[14
]}

Junior, Laurindo Rocha ^{[15
]}

Brito, Danielle E. ^{[16
]}

Fernandino, Diana C. ^{[17
]}

Yazbek, Michel A. ^{[18
]}

Souza, Mariana P. G. ^{[19
]}

Ximenes, Antonio Carlos ^{[20
]}

Martins, Ana Silvia S. ^{[21
]}

Castro, Glaucio Ricardo W. ^{[22
]}

Oliveira, Livia C. ^{[23
]}

Freitas, Ana Beatriz S. B. ^{[24
]}

Kakehasi, Adriana M. ^{[8
]}

Gomides, Ana Paula M. ^{[25
]}

Reis Neto, Edgard Torres ^{[7
]}

Pileggi, Gecilmara S. ^{[7
]}

Ferreira, Gilda A. ^{[8
]}

Mota, Licia Maria H. ^{[26
,27
]}

Xavier, Ricardo M. ^{[6
]}

Pinheiro, Marcelo de Medeiros ^{[7
]}

机构：

[1] Hosp Clin Univ Fed Pernambuco, Recife, PE, Brazil

[2] Univ Fed Amazonas, Manaus, Amazonas, Brazil

[3] Univ Brasilia Hub UnB EBSERH, Brasilia, DF, Brazil

[4] Hosp Geral Fortaleza HGF, Fortaleza, Ceara, Brazil

[5] Hosp Getulio Vargas, Recife, PE, Brazil

[6] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil

[7] Univ Fed Sao Paulo, Rua Borges Lagoa 913-51-53, BR-04038034 Sao Paulo, SP, Brazil

[8] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG, Brazil

[9] Fundacao Hosp Acre Fundhacre, Rio Branco, Brazil

[10] Hosp Servidores Sao Paulo IAMSPE, Sao Paulo, Brazil

[11] Univ Sao Paulo, Hosp Clin, Sao Paulo, Brazil

[12] Univ Estado Rio de Janeiro, Hosp Univ Pedro Ernesto, Abraao, Brazil

[13] Clin Omura Med Diagnost, Sao Paulo, Brazil

[14] Univ Fed Goias, Fac Med, Goiania, Go, Brazil

[15] Inst Med Integral Prof Fernando Figueira IMIP, Recife, PE, Brazil

[16] Univ Fed Paraiba, Joao Pessoa, Paraiba, Brazil

[17] Univ Fed Juiz de Fora, Juiz De Fora, Brazil

[18] Hosp Clin Univ Estadual Campinas UNICAMP, Campinas, Brazil

[19] Santa Casa Belo Horizonte, Belo Horizonte, MG, Brazil

[20] CIP Ctr Int Pesquisa, Goiania, Go, Brazil

[21] Univ Fed Uberlandia, Hosp Clin, Uberlandia, MG, Brazil

[22] Hosp Governador Celso Ramos Santa Catarina, Florianopolis, SC, Brazil

[23] Hosp Santa Casa Misericordia Vitoria, Vitoria, ES, Brazil

[24] Fac Ciencias Saude Paulo Prata FACISB, Barretos, Brazil

[25] UniCEUB, Brasilia, DF, Brazil

[26] Univ Brasilia PPGCM FM UnB, Fac Med, Programa Posgrad Ciencias Med, Brasilia, DF, Brazil

[27] Hosp Univ Brasilia Hub UnB EBSERH, Brasilia, DF, Brazil

来源：

ADVANCES IN RHEUMATOLOGY | 2022年 / 62卷 / 01期

关键词：

COVID-19; Hospitalization; Spondyloarthritis; Psoriatic arthritis; SARS-CoV-2; ANKYLOSING-SPONDYLITIS; RHEUMATIC-DISEASES; CLASSIFICATION CRITERIA; GEOGRAPHIC-DISTRIBUTION; ARTHRITIS; LEFLUNOMIDE; INFECTION; HLA-B27; RISK;

D O I：

10.1186/s42358-022-00268-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To evaluate the disease activity before and after COVID-19 and risk factors associated with outcomes, including hospitalization, intensive care unit (ICU) admission, mechanical ventilation (MV) and death in patients with spondylarthritis (SpA). Methods ReumaCoV Brazil is a multicenter prospective cohort of immune-mediated rheumatic diseases (IMRD) patients with COVID-19 (case group), compared to a control group of IMRD patients without COVID-19. SpA patients enrolled were grouped as axial SpA (axSpA), psoriatic arthritis (PsA) and enteropathic arthritis, according to usual classification criteria. Results 353 SpA patients were included, of whom 229 (64.9%) were axSpA, 118 (33.4%) PsA and 6 enteropathic arthritis (1.7%). No significant difference was observed in disease activity before the study inclusion comparing cases and controls, as well no worsening of disease activity after COVID-19. The risk factors associated with hospitalization were age over 60 years (OR = 3.71; 95% CI 1.62-8.47, p = 0.001); one or more comorbidities (OR = 2.28; 95% CI 1.02-5.08, p = 0.001) and leflunomide treatment (OR = 4.46; 95% CI 1.33-24.9, p = 0.008). Not having comorbidities (OR = 0.11; 95% CI 0.02-0.50, p = 0.001) played a protective role for hospitalization. In multivariate analysis, leflunomide treatment (OR = 8.69; CI = 95% 1.41-53.64; p = 0.023) was associated with hospitalization; teleconsultation (OR = 0.14; CI = 95% 0.03-0.71; p = 0.01) and no comorbidities (OR = 0.14; CI = 95% 0.02-0.76; p = 0.02) remained at final model as protective factor. Conclusions Our results showed no association between pre-COVID disease activity or that SARS-CoV-2 infection could trigger disease activity in patients with SpA. Teleconsultation and no comorbidities were associated with a lower hospitalization risk. Leflunomide remained significantly associated with higher risk of hospitalization after multiple adjustments.

引用

页数：13

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