Synthesis and Anti-Inflammatory Activity of Novel Calix[4]Arene Derivatives Containing an Ibuprofen Residue

被引：1

作者：

Kravchenko, I. A. ^{[1
,2
]}

Alekseeva, E. A. ^{[2
]}

Aleksandrova, A. I. ^{[1
]}

Kobernik, A. A. ^{[1
]}

机构：

[1] II Mechnikov Odessa Natl Univ, Odessa, Ukraine

[2] Ukrainian Natl Acad Sci, AV Bogatskii Physicochem Inst, Odessa, Ukraine

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 49卷 / 03期

关键词：

calix[4]arenes; ibuprofen; anti-inflammatory activity; carrageenan edema; CALIXARENES; CELECOXIB;

D O I：

10.1007/s11094-015-1245-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel derivatives based on calix[4]arene and ibuprofen were prepared. Physicochemical analysis methods were used to identify these compounds. Studies of their anti-inflammatory actions in a carrageenan edema model showed that these substances had greater anti-inflammatory effects than ibuprofen.

引用

页码：163 / 166

页数：4

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