Cucurbit[7]uril assisted ultraviolet to visible fluorescence switch of a heart medicine

被引：24

作者：

Gavvala, Krishna ^{[1
]}

Koninti, Raj Kumar ^{[1
]}

Sengupta, Abhigyan ^{[1
]}

Hazra, Partha ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem, Pune, Maharashtra, India

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2014年 / 16卷 / 07期

关键词：

ANTICANCER DRUG; AMRINONE; HEMODYNAMICS; NANOCAVITIES; METABOLISM; COMPLEXES; MILRINONE; DYNAMICS; FAILURE;

D O I：

10.1039/c3cp54895c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Host-guest interactions between cucurbit[7]uril (CB7) and a cardiotonic drug, milrinone, have been explored using steady state and pico-second time-resolved techniques. A novel fluorescence switch from ultraviolet (UV) to visible (cyan) is observed as a consequence of upward pKa shift of the drug inside the nano-cavity of cucurbit[7]uril.

引用

页码：2823 / 2826

页数：4

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