Quassinoids from Picrasma quassioides and Their Neuroprotective Effects

被引：44

作者：

Zhao, Wen-Yu ^{[1
,2
]}

Song, Xiao-Yu ^{[1
,2
]}

Zhao, Lu ^{[1
,2
]}

Zou, Chun-Xin ^{[1
,2
]}

Zhou, Wei-Yu ^{[1
,2
]}

Lin, Bin ^{[2
,3
]}

Yao, Guo-Dong ^{[1
,2
]}

Huang, Xiao-Xiao ^{[1
,2
,4
]}

Song, Shao-Jiang ^{[1
,2
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Materia Med, Shenyang 110016, Liaoning, Peoples R China

[2] Shenyang Pharmaceut Univ, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China

[4] Chinese Peoples Liberat Army 210 Hosp, Dalian 116021, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 04期

关键词：

STEM WOOD; ENONES; BARK;

D O I：

10.1021/acs.jnatprod.8b00470

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Quassinoids are a class of highly oxygenated degraded triterpenoids exclusively discovered from plants of the Simaroubaceae family. In this study, eight new (1-8) and 15 known quassinoids (9-23) were isolated from an extract of the stems of Picrasma quassioides. The structures were elucidated by spectroscopic analysis and electronic circular dichroism spectra combined with quantum chemical calculations. Compounds 4 and 5 represent the first examples of 18-nor-quassinoids from P. quassioides. All isolates were screened for their neuroprotective activities toward H2O2-induced cell damage in SH-SYSY cells. Further study revealed that the potential protective activities of these compounds appeared to occur via the suppression of cell apoptosis and downregulation of caspase-3 activation.

引用

页码：714 / 723

页数：10

共 28 条

[1] QUASSINOIDS FROM QUASSIA-AMARA [J].