Is sequential therapy superior to standard triple therapy for the treatment of Helicobacter pylori infection?

被引:8
作者
O'Morain, Colm A. [1 ]
O'Connor, J. P. Anthony [1 ]
机构
[1] Trinity Coll Dublin, Dept Gastroenterol, Dublin, Ireland
来源
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2009年 / 6卷 / 01期
关键词
antibiotic resistance; Helicobacter pylori infection; sequential therapy; treatment; triple therapy;
D O I
10.1038/ncpgasthep1276
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The challenges posed in the treatment of Helicobacter pylori are increasing: falling rates of eradication and the rising prevalence of antibiotic-resistant H. pylori strains have led to a decline in cure rates. Sequential therapy has been proposed as an alternative to standard triple therapy. The fundamental basis of sequential therapy lies in its superior ability to overcome antibiotic resistance, particularly clarithromycin resistance. The meta-analysis by Jafri et al. shows a potential benefit from using this treatment regimen, but several methodological and practical limitations affect the strength of their conclusions. Greater scrutiny and better designed trials across a much broader range of patients are necessary before guidelines could be supplanted. An expanded role for culture and sensitivity testing might offer the best long-term prospect for the management of H. pylori infection, rather than empirical regimens.
引用
收藏
页码:8 / 9
页数:2
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