Methylation of KLF5 contributes to reduced expression in acute myeloid leukaemia and is associated with poor overall survival

被引：17

作者：

Diakiw, Sonya M. ^{[1
,2
,3
,4
]}

Perugini, Michelle ^{[1
,2
,3
,4
]}

Kok, Chung H. ^{[1
,3
,4
]}

Engler, Grant A. ^{[1
,3
,4
]}

Cummings, Nik ^{[5
,6
]}

To, Luen Bik ^{[1
,3
,4
,7
]}

Wei, Andrew H. ^{[5
,6
]}

Lewis, Ian D. ^{[1
,3
,4
,7
]}

Brown, Anna L. ^{[1
,2
,3
,4
]}

D'Andrea, Richard J. ^{[1
,2
,3
,4
,8
,9
]}

机构：

[1] SA Pathol, Haematol Directorate, Adelaide, SA, Australia

[2] Univ Adelaide, Sch Mol & Biomed Sci, Adelaide, SA, Australia

[3] Univ Adelaide, Ctr Personalised Canc Med, Adelaide, SA, Australia

[4] Univ Adelaide, Sch Med, Adelaide, SA, Australia

[5] Alfred Hosp, Dept Clin Haematol, Melbourne, Vic, Australia

[6] Monash Univ, Melbourne, Vic 3004, Australia

[7] Royal Adelaide Hosp, Dept Haematol, Adelaide, SA 5000, Australia

[8] Queen Elizabeth Hosp, Dept Haematol & Oncol, Adelaide, SA, Australia

[9] Queen Elizabeth Hosp, Basil Hetzel Inst Translat Hlth Res, Adelaide, SA, Australia

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2013年 / 161卷 / 06期

关键词：

kruppel-like factor 5; acute myeloid leukaemia; transcriptional regulation; methylation; prognostic biomarkers;

D O I：

10.1111/bjh.12295

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：884 / 888

页数：5

共 10 条

[1] The granulocyte-associated transcription factor Kruppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia [J].

Diakiw, Sonya M. ;

Kok, Chung H. ;

To, L. Bik ;

Lewis, Ian D. ;

Brown, Anna L. ;

D'Andrea, Richard J. .

LEUKEMIA RESEARCH, 2012, 36 (01) :110-116

[2] Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases [J].

Dong, Jin-Tang ;

Chen, Ceshi .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (16) :2691-2706

[3] Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials [J].

Grimwade, David ;

Hills, Robert K. ;

Moorman, Anthony V. ;

Walker, Helen ;

Chatters, Stephen ;

Goldstone, Anthony H. ;

Wheatley, Keith ;

Harrison, Christine J. ;

Burnett, Alan K. .

BLOOD, 2010, 116 (03) :354-365

[4] Deregulated expression of Kruppel-like factors in acute myeloid leukemia [J].

Humbert, Magali ;

Halter, Veronika ;

Shan, Deborah ;

Laedrach, Judith ;

Leibundgut, Elisabeth Oppliger ;

Baerlocher, Gabriela M. ;

Tobler, Andreas ;

Fey, Martin F. ;

Tschan, Mario P. .

LEUKEMIA RESEARCH, 2011, 35 (07) :909-913

[5] DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables [J].

Kamalakaran, Sitharthan ;

Varadan, Vinay ;

Russnes, Hege E. Giercksky ;

Levy, Dan ;

Kendall, Jude ;

Janevski, Angel ;

Riggs, Michael ;

Banerjee, Nilanjana ;

Synnestvedt, Marit ;

Schlichting, Ellen ;

Karesen, Rolf ;

Prasada, K. Shama ;

Rotti, Harish ;

Rao, Ramachandra ;

Rao, Laxmi ;

Tang, Man-Hung Eric ;

Satyamoorthy, K. ;

Lucito, Robert ;

Wigler, Michael ;

Dimitrova, Nevenka ;

Naume, Bjorn ;

Borresen-Dale, Anne-Lise ;

Hicks, James B. .

MOLECULAR ONCOLOGY, 2011, 5 (01) :77-92

[6] Expression of Kruppel-like factor 5 in human gastric carcinomas [J].

Kwak, Mi Kyung ;

Lee, Hyuk-Joon ;

Hur, Keun ;

Park, Do Joong ;

Lee, Hye Seung ;

Kim, Woo Ho ;

Lee, Kuhn Uk ;

Choe, Kuk Jin ;

Guilford, Parry ;

Yang, Han-Kwang .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2008, 134 (02) :163-167

[7] Molecular Genetics of Adult Acute Myeloid Leukemia: Prognostic and Therapeutic Implications [J].

Marcucci, Guido ;

Haferlach, Torsten ;

Doehner, Hartmut .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (05) :475-486

[8] Regulatory polymorphism in transcription factor KLF5 at the MEF2 element alters the response to angiotensin II and is associated with human hypertension [J].

Oishi, Yumiko ;

Manabe, Ichiro ;

Imai, Yasushi ;

Hara, Kazuo ;

Horikoshi, Momoko ;

Fujiu, Katsuhito ;

Tanaka, Toshihiro ;

Aizawa, Tadanori ;

Kadowaki, Takashi ;

Nagai, Ryozo .

FASEB JOURNAL, 2010, 24 (06) :1780-1788

[9] DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences [J].

Thomas, Xavier .

EXPERT OPINION ON DRUG DISCOVERY, 2012, 7 (11) :1039-1051

[10] Expression of Kruppel-like factor 5 gene in human brain and association of the gene with the susceptibility to schizophrenia [J].

Yanagi, Masaya ;

Hashimoto, Takeshi ;

Kitamura, Noboru ;

Fukutake, Masaaki ;

Komure, Osamu ;

Nishiguchi, Naoki ;

Kawamata, Toshio ;

Maeda, Kiyoshi ;

Shirakawa, Osamu .

SCHIZOPHRENIA RESEARCH, 2008, 100 (1-3) :291-301

← 1 →