Metabolism of sphingolipids in the gut and its relation to inflammation and cancer development

被引：164

作者：

Duan, Rui-Dong ^{[1
]}

Nilsson, Ake ^{[2
]}

机构：

[1] Lund Univ, Dept Clin Sci, Gastroenterol Lab, Biomed Ctr B11, S-22184 Lund, Sweden

[2] Univ Lund Hosp, Dept Clin Sci, Div Gastroenterol, S-22185 Lund, Sweden

来源：

PROGRESS IN LIPID RESEARCH | 2009年 / 48卷 / 01期

基金：

瑞典研究理事会;

关键词：

Ceramide; Ceramidase; Ceramide kinase; Colon cancer; Glucosylceramide; Inflammatory bowel disease; Intestine; Sphingolipid; Sphingosine; Sphingosine kinase; Sphingosine-1-phosphatase; Sphingomyelin; Sphingomyelinase; INTESTINAL ALKALINE SPHINGOMYELINASE; LIPID PHOSPHATE PHOSPHATASES; SPHINGOSINE; 1-PHOSPHATE; COLON-CANCER; MOLECULAR-CLONING; EPITHELIAL-CELLS; GLUCOSYLCERAMIDE SYNTHASE; NEUTRAL CERAMIDASE; GLYCOSPHINGOLIPID COMPOSITION; ALPHA-GALACTOSYLCERAMIDE;

D O I：

10.1016/j.plipres.2008.04.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingolipids are abundant in the microvillar membrane of intestinal epithelial cells where they are essential for structural integrity and may act as receptors for toxins, virus and bacteria. Metabolism of dietary and membrane sphingolipids in the intestine generates ceramide, sphingosine, sphingosine-1-phosphate, and ceramide-1-phosphate, via the action of alkaline sphingomyelinase, neutral cerarmidase, sphingosine-l-kinase, and ceramide-l-kinase. These intermediary metabolites act as bioactive lipid messengers, influencing numerous cellular functions including growth, differentiation and apoptosis of both epithelial and immunocompetent cells in the gastrointestinal tract, and also the progress of inflammation and responsiveness of the mucosal cells to pathogens. This review summarizes background and recent progress in the metabolism of dietary and endogenous sphingolipids in the gut and its pathophysiological implications. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：62 / 72

页数：11

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