Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?

被引：52

作者：

Guo, Ai ^{[1
]}

Li, Kai ^{[2
]}

Xiao, Qian ^{[1
]}

机构：

[1] Chongqing Med Univ, Dept Geriatr, Affiliated Hosp 1, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Chongqing 400016, Peoples R China

来源：

EXPERIMENTAL GERONTOLOGY | 2020年 / 139卷

基金：

中国国家自然科学基金;

关键词：

Myokines; Skeletal muscle; Sarcopenic obesity; Sarcopenia; Biomarker; LEUKEMIA INHIBITORY FACTOR; HUMAN SKELETAL-MUSCLE; FATTY-ACID OXIDATION; GROWTH-FACTOR; 21; BETA-AMINOISOBUTYRIC ACID; SERUM IRISIN LEVELS; FOLLISTATIN-LIKE; LEAN BODY-MASS; INSULIN-RESISTANCE; NEUROTROPHIC FACTOR;

D O I：

10.1016/j.exger.2020.111022

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Sarcopenic obesity (SO) is a condition characterized by the occurrence of both sarcopenia and obesity and imposes a heavy burden on the health of the elderly. Controversies and challenges regarding the definition, diagnosis and treatment of SO still remain because of its complex pathogenesis and limitations. Over the past few decades, numerous studies have revealed that myokines secreted from skeletal muscle play significant roles in the regulation of muscle mass and function as well as metabolic homeostasis. Abnormalities in myokines may trigger and promote the pathogenesis underlying age-related and metabolic diseases, including obesity, sarcopenia, type 2 diabetes (T2D), and SO. This review mainly focuses on the role of myokines as potential biomarkers for the early diagnosis and therapeutic targets in SO.

引用

页数：15

共 287 条

[1] Insulin resistance and muscle strength in older persons [J].

Abbatecola, AM ;

Ferrucci, L ;

Ceda, G ;

Russo, CR ;

Lauretani, F ;

Bandinelli, S ;

Barbieri, M ;

Valenti, G ;

Paolisso, G .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2005, 60 (10) :1278-1282

[2]

Achari A.E., 2017, ADIPONECTIN THERAPEU

[3] Connecting Myokines and Metabolism [J].

Ahima, Rexford S. ;

Park, Hyeong-Kyu .

ENDOCRINOLOGY AND METABOLISM, 2015, 30 (03) :235-245

[4] RETRACTED: Exercise induces interleukin-8 expression in human skeletal muscle (Retracted article. See vol. 589, pg. 3407, 2011) [J].

Akerstrom, T ;

Steensberg, A ;

Keller, P ;

Keller, C ;

Penkowa, M ;

Pedersen, BK .

JOURNAL OF PHYSIOLOGY-LONDON, 2005, 563 (02) :507-516

[5] Signaling specificity of interleukin-6 action on glucose and lipid metabolism in skeletal muscle [J].

Al-Khalili, Lubna ;

Bouzakri, Karim ;

Glund, Stephan ;

Lonnqvist, Fredrik ;

Koistinen, Heikki A. ;

Krook, Anna .

MOLECULAR ENDOCRINOLOGY, 2006, 20 (12) :3364-3375

[6] Mechanisms of cytosolic targeting of matrix metalloproteinase-2 [J].

Ali, Mohammad A. M. ;

Chow, Ava K. ;

Kandasamy, Arulmozhi D. ;

Fan, Xiaohu ;

West, Lori J. ;

Crawford, Bryan D. ;

Simmen, Thomas ;

Schulz, Richard .

JOURNAL OF CELLULAR PHYSIOLOGY, 2012, 227 (10) :3397-3404

[7] Increased Expression of Meteorin-Like Hormone in Type 2 Diabetes and Obesity and Its Association with Irisin [J].

AlKhairi, Irina ;

Cherian, Preethi ;

Abu-Farha, Mohamed ;

Al Madhoun, Ashraf ;

Nizam, Rasheeba ;

Melhem, Motasem ;

Jamal, Mohamed ;

Al-Sabah, Suleiman ;

Ali, Hamad ;

Tuomilehto, Jaakko ;

Al-Mulla, Fahd ;

Abubaker, Jehad .

CELLS, 2019, 8 (10)

[8] Aging is associated with circulating cytokine dysregulation [J].

Alvarez-Rodriguez, Lorena ;

Lopez-Hoyos, Marcos ;

Munoz-Cacho, Pedro ;

Manuel Martinez-Taboada, Victor .

CELLULAR IMMUNOLOGY, 2012, 273 (02) :124-132

[9] Serum Myostatin is Upregulated in Obesity and Correlates with Insulin Resistance in Humans [J].

Amor, Melina ;

Itariu, Bianca K. ;

Moreno-Viedma, Veronica ;

Keindl, Magdalena ;

Juerets, Alexander ;

Prager, Gerhard ;

Langer, Felix ;

Grablowitz, Viktor ;

Zeyda, Maximilian ;

Stulnig, Thomas M. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2019, 127 (08) :550-556

[10]

[Anonymous], J ENDOCRINOL

← 1 2 3 4 5 6 7 8 9 10 →