Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma

被引：10

作者：

Clarke, Loren E. ^{[1
,2
]}

Conway, Andrea B. ^{[3
]}

Warner, Nicole M. ^{[1
]}

Barnwell, Patricia N.

Sceppa, Jennifer ^{[4
]}

Helm, Klaus F. ^{[1
,2
]}

机构：

[1] Penn State Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

[2] Penn State Hershey Med Ctr, Dept Dermatol, Hershey, PA 17033 USA

[3] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[4] Dermatol Associates Lancaster, Lancaster, PA USA

来源：

JOURNAL OF CUTANEOUS PATHOLOGY | 2013年 / 40卷 / 07期

关键词：

Ber-Ep4; Cam; 5; 2; cutaneous; cytokeratin; 7; squamous cell carcinoma; EXTRAMAMMARY PAGETS-DISEASE; CYTOKERATIN; 20; EXPRESSION; IN-SITU; NEUROENDOCRINE CARCINOMA; MAMMARY; SKIN; HISTOGENESIS; NEOPLASMS; PROFILE; LESION;

D O I：

10.1111/cup.12135

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs. Methods We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD. Results We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4. Conclusions We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.

引用

页码：646 / 650

页数：5

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