Cognitive and emotional control of pain and its disruption in chronic pain

被引:1433
作者
Bushnell, M. Catherine [1 ]
Ceko, Marta [1 ]
Low, Lucie A. [1 ]
机构
[1] NIH, Natl Ctr Complementary & Alternat Med, Bethesda, MD 20892 USA
关键词
IRRITABLE-BOWEL-SYNDROME; CHRONIC LOW-BACK; ANTERIOR CINGULATE CORTEX; MU-OPIOID RECEPTOR; NOXIOUS THERMAL-STIMULATION; POSTERIOR PARIETAL CORTEX; LONG-TERM POTENTIATION; GRAY-MATTER; DECISION-MAKING; PLACEBO ANALGESIA;
D O I
10.1038/nrn3516
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic pain is one of the most prevalent health problems in our modern world, with millions of people debilitated by conditions such as back pain, headache and arthritis. To address this growing problem, many people are turning to mind-body therapies, including meditation, yoga and cognitive behavioural therapy. This article will review the neural mechanisms underlying the modulation of pain by cognitive and emotional states -important components of mind-body therapies. It will also examine the accumulating evidence that chronic pain itself alters brain circuitry, including that involved in endogenous pain control, suggesting that controlling pain becomes increasingly difficult as pain becomes chronic.
引用
收藏
页码:502 / 511
页数:10
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