Microbiological Screening of Platelet Concentrates in Europe

被引:37
作者
Prax, Marcel [1 ]
Bekeredjian-Ding, Isabelle [1 ]
Krut, Oleg [1 ]
机构
[1] Paul Ehrlich Inst, Div Microbiol, Paul Ehrlich Str 51-59, DE-63225 Langen, Germany
关键词
Bacterial contamination; Blood safety; Infection; Sepsis; Platelet concentrates; Pathogen inactivation; Transfusion-associated infections; TRANSMITTED BACTERIAL-INFECTIONS; TRANSFUSION-RELEVANT BACTERIA; APHERESIS PLATELETS; PATHOGEN INACTIVATION; STAPHYLOCOCCUS-EPIDERMIDIS; INTERNATIONAL REPOSITORY; PROPIONIBACTERIUM-ACNES; BLOOD COMPONENTS; RESIDUAL RISK; SAMPLE VOLUME;
D O I
10.1159/000499349
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The risk of transfusion-associated sepsis due to transmission of bacteria is a persistent problem in the transfusion field. Despite numerous interventions to reduce the risk, cases of bacterial sepsis following transfusion are repeatedly being reported. Especially platelet concentrates are highly susceptible to bacterial contaminations due to the growth-promoting storage conditions. In Europe, blood establishments and national authorities have implemented individual precaution measures to mitigate the risk of bacterial transmission. To obtain an overview of the different approaches, we compiled information from national authorities, blood establishments, and the current literature. Several aspects such as the shelf life of platelets, time of sampling and the applied control measures are compared between the member states. The analysis of the data revealed a broad heterogeneity of procedures on a national level ranging from platelet release without any safety testing up to mandatory screening of all platelet concentrates prior to transfusion. Despite the substantial progress made in recent years, several bacterial reports on transfusion-associated sepsis indicate that further efforts are needed to increase the safety of blood transfusions in the long term. (c) 2019 S. Karger AG, Basel
引用
收藏
页码:76 / 86
页数:11
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