Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-Expansion Reaction of Cyclic Oxime with DIBAL-H: Facile Synthesis of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitor

被引：7
作者：
Cho, Hidetsura [1 ,2 ]
Iwama, Yusuke [2 ]
Okano, Kentaro [2 ]
Tokuyama, Hidetoshi [2 ]
机构：
[1] Tohoku Univ, Grad Sch Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
[2] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
SYNLETT | 2013年 / 24卷 / 07期
关键词：
reduction; ring expansion; rearrangement; heterocycles; regioselectivity; PENTOXIDE-METHANESULFONIC ACID; AROMATIC RING; HETEROCYCLES; HYDRIDE;
D O I：
10.1055/s-0032-1318489
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Synthetic studies on a 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitor are described. The unsymmetrical dibenzazocine skeleton was constructed by a regiocontrolled ring-expansion reaction of a cyclic oxime with DIBAL-H.
引用
收藏
页码：813 / 816
页数：4
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