Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp 16-5c

被引：111

作者：

Huang, Xishan ^{[1
]}

Huang, Hongbo ^{[1
]}

Li, Hanxiang ^{[1
]}

Sun, Xuefeng ^{[1
]}

Huang, Huarong ^{[1
]}

Lu, Yongjun ^{[2
]}

Lin, Yongcheng ^{[1
]}

Long, Yuhua ^{[1
]}

She, Zhigang ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 04期

关键词：

FUNGUS; IMPAIRS;

D O I：

10.1021/ol303549c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC50 value of 2.2 mu M.

引用

页码：721 / 723

页数：3

共 22 条

[1] Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages [J].

Beresford, Nicola J. ;

Mulhearn, Debbie ;

Szczepankiewicz, Bruce ;

Liu, Gang ;

Johnson, Michael E. ;

Fordham-Skelton, Anthony ;

Abad-Zapatero, Cele ;

Cavet, Jennifer S. ;

Tabernero, Lydia .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 63 (05) :928-936

[2] Inhibitors of protein tyrosine phosphatases: Next-generation drugs? [J].

Bialy, L ;

Waldmann, H .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (25) :3814-3839

[3] New fronts in an old war [J].

Butler, D .

NATURE, 2000, 406 (6797) :670-672

[4] Protein phosphatase inhibitors isolated from Spongia irregularis collected in Papua New Guinea [J].

Carr, Gavin ;

Raszek, Mikolaj ;

Van Soest, Rob ;

Matainaho, Teatulohi ;

Shopik, Micheal ;

Holmes, Charles F. B. ;

Andersen, Raymond J. .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (11) :1812-1815

[5] Aspergilloxide, a novel sesterterpene epoxide from a marine-derived fungus of the genus Aspergillus [J].

Cueto, M ;

Jensen, PR ;

Fenical, W .

ORGANIC LETTERS, 2002, 4 (09) :1583-1585

[6] Ansellone A, a Sesterterpenoid Isolated from the Nudibranch Cadlina luteromarginata and the Sponge Phorbas sp., Activates the cAMP Signaling Pathway [J].

Daoust, Julie ;

Fontana, Angelo ;

Merchant, Catherine E. ;

de Voogd, Nicole J. ;

Patrick, Brian O. ;

Kieffer, Timothy J. ;

Andersen, Raymond J. .

ORGANIC LETTERS, 2010, 12 (14) :3208-3211

[7] Terpenes from Marine-Derived Fungi [J].

Ebel, Rainer .

MARINE DRUGS, 2010, 8 (08) :2340-2368

[8] ON ENANTIOMORPH-POLARITY ESTIMATION [J].

FLACK, HD .

ACTA CRYSTALLOGRAPHICA SECTION A, 1983, 39 (NOV) :876-881

[9] Alotaketals A and B, Sesterterpenoids from the Marine Sponge Hamigera Species that Activate the cAMP Cell Signaling Pathway [J].

Forestier, Roberto ;

Merchant, Catherine E. ;

de Voogd, Nicole J. ;

Matainaho, Teatulohi ;

Kieffer, Timothy J. ;

Andersen, Raymond J. .

ORGANIC LETTERS, 2009, 11 (22) :5166-5169

[10] Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea [J].

Huang, Hongbo ;

Feng, Xiaojun ;

Xiao, Ze'en ;

Liu, Lan ;

Li, Hanxiang ;

Ma, Lin ;

Lu, Yongjun ;

Ju, Jianhua ;

She, Zhigang ;

Lin, Yongcheng .

JOURNAL OF NATURAL PRODUCTS, 2011, 74 (05) :997-1002

← 1 2 3 →