Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp 16-5c

被引：110
作者：
Huang, Xishan [1 ]
Huang, Hongbo [1 ]
Li, Hanxiang [1 ]
Sun, Xuefeng [1 ]
Huang, Huarong [1 ]
Lu, Yongjun [2 ]
Lin, Yongcheng [1 ]
Long, Yuhua [1 ]
She, Zhigang [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 04期
关键词：
FUNGUS; IMPAIRS;
D O I：
10.1021/ol303549c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC50 value of 2.2 mu M.
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收藏
页码：721 / 723
页数：3
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