Drosophila, Chitin and Insect Pest Management

被引:8
作者
Wang, Yiwen [1 ]
Gao, Lujuan [1 ]
Moussian, Bernard [2 ,3 ]
机构
[1] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China
[2] Univ Tubingen, Interfac Inst Cell Biol Ifiz, Morgenstelle 15, D-72076 Tubingen, Germany
[3] Univ Cote dAzur, CNRS, INSERM, Inst Biol Valrose, Parc Valrose, F-06108 Nice 2, France
关键词
Drosophila ndanogaster; insecticide; xenobiotics; chitin; cuticle; hio-medical research; SULFONYLUREA RECEPTOR SUR; CUTICLE DIFFERENTIATION; RESISTANCE; MELANOGASTER; KNICKKOPF; ORGANIZATION; MATRIX; NEONICOTINOIDS; BIOSYNTHESIS; INHIBITION;
D O I
10.2174/1381612826666200721002354
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Insects are a great menace in agriculture and vectors of human diseases. Hence, controlling insect populations is an important issue worldwide. A common strategy to control insects is the application of insecticides. However, insecticides entail three major problems. First, insecticides are chemicals that stress ecosystems and may even be harmful to humans. Second, insecticides are often unspecific and also eradicate beneficial insect species like the honeybee. Third, insects are able to develop resistance to insecticides. Therefore, the efficient generation of new potent insecticides and their intelligent delivery are the major tasks in agriculture. In addition, acceptance or refusal in society is a major issue that has to be considered in the application of a pest management strategy. In this paper, we unify two issues: 1) we illustrate that our molecular knowledge of the chitin synthesis and organization pathways may offer new opportunities to design novel insecticides that are environmentally harmless at the same time being specific to a pest species; and 2) we advocate that the fruit fly Drosophila melanogaster may serve as an excellent model of insect to study the effects of insecticides at the genetic, molecular and histology level in order to better understand their mode of action and to optimize their impact. Especially, chitin synthesis and organization proteins and enzymes are excellently dissected in the fruit fly, providing a rich source for new insecticide targets. Thus, D. melanogaster offers a cheap, efficient and fast assay system to address agricultural questions, as has been demonstrated to be the case in bin-medical research areas.
引用
收藏
页码:3546 / 3553
页数:8
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