Determination of sedatives and adrenergic blockers in blood meal using accelerated solvent extraction and Orbitrap mass spectrometry

被引：24

作者：

Choi, Jeong-Heui ^{[1
,2
]}

Lamshoeft, Marc ^{[2
]}

Zuehlke, Sebastian ^{[2
]}

Park, Ki Hun ^{[1
]}

Shim, Jae-Han ^{[1
]}

Spiteller, Michael ^{[2
]}

机构：

[1] Chonnam Natl Univ, Coll Agr & Life Sci, Nat Prod Chem Lab, Kwangju 500757, South Korea

[2] Dortmund Univ Technol, Fac Chem, Inst Environm Res, D-44227 Dortmund, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2012年 / 1260卷

基金：

新加坡国家研究基金会;

关键词：

Sedatives; alpha-; beta-blockers; Accelerated solvent extraction; Dispersive solid-phase extraction; Orbitrap mass spectrometry; Environment-friendly agricultural material; PRESSURIZED-LIQUID EXTRACTION; MULTIRESIDUE METHOD; SEWAGE-SLUDGE; BETA-BLOCKER; LC-MS/MS; CHROMATOGRAPHY; RESIDUES; PHARMACEUTICALS; TRANQUILIZERS; SULFONAMIDES;

D O I：

10.1016/j.chroma.2012.08.060

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The detection of veterinary drugs in blood meal is needed since it is used as an environment-friendly agricultural material despite its origination from animal blood. A method using accelerated solvent extraction and liquid chromatographic linear ion trap quadrupole Orbitrap mass spectrometry was developed to determine sedatives and adrenergic blockers in blood meal. The determination method was established following optimizations of accelerated solvent extraction, dispersive solid-phase extraction and high resolution mass spectrometric detection. Linearity, sensitivity, accuracy, repeatability and reproducibility of the method were fully validated. The method was applied to commercial blood meal products. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：111 / 119

页数：9

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