Novel Mg-organic reagents in organic synthesis. Cp2TiCl2 catalyzed intermolecular cyclomagnesiation of cyclic and acyclic 1,2-dienes using Grignard reagents

被引：44

作者：

D'yakonov, Vladimir A. ^{[1
]}

Makarov, Aleksey A. ^{[1
]}

Ibragimov, Askhat G. ^{[1
]}

Khalilov, Leonard M. ^{[1
]}

Dzhemilev, Usein M. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Petrochem & Catalysis, Ufa 450075, Russia

来源：

TETRAHEDRON | 2008年 / 64卷 / 44期

关键词：

Metallacycles; Cyclomagnesiation; Allenes; Homogeneous catalysis; Titanium; Dzhemilev reaction;

D O I：

10.1016/j.tet.2008.08.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High-yield (> 80%) catalytic intermolecular cyclomagnesiation of cyclic and acyclic allenes with the aid of Grignard reagents has been realized in the presence of Cp2TiCl2. The synthesized unsaturated bi- and tricyclic organomagnesium compounds (OMC) have been successfully converted in situ into thiophenes, unsaturated ketones, cyclic and acyclic hydrocarbons with high regio- and stereoselectivity. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：10188 / 10194

页数：7

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