Adsorption and Release of Rose Bengal on Layer-by-Layer Films of Poly(Vinyl Alcohol) and Poly(Amidoamine) Dendrimers Bearing 4-Carboxyphenylboronic Acid

被引：2

作者：

Yoshida, Kentaro ^{[1
]}

Yamaguchi, Akane ^{[1
]}

Midorikawa, Hiroki ^{[1
]}

Kamijo, Toshio ^{[2
]}

Ono, Tetsuya ^{[1
]}

Dairaku, Takenori ^{[1
]}

Sato, Takaya ^{[2
]}

Fujimura, Tsutomu ^{[3
]}

Kashiwagi, Yoshitomo ^{[1
]}

Sato, Katsuhiko ^{[2
,3
]}

机构：

[1] Ohu Univ, Sch Pharmaceut Sci, 31-1 Misumido,Tomita Machi, Koriyama, Fukushima 9638611, Japan

[2] Tsuruoka Coll, Natl Inst Technol, Dept Creat Engn, 104 Sawada, Tsuruoka, Yamagata 9978511, Japan

[3] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan

来源：

POLYMERS | 2020年 / 12卷 / 08期

基金：

日本学术振兴会;

关键词：

layer-by-layer films; dendrimer; boronic acid; release system; thin film; MULTILAYER FILMS; PH; POLYSACCHARIDES; NANOPARTICLES; INSULIN; TUMOR;

D O I：

10.3390/polym12081854

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Phenylboronic acid-bearing polyamidoamine dendrimer (PBA-PAMAM)/poly(vinyl alcohol) (PVA) multilayer films were prepared through the layer-by-layer (LbL) deposition of PBA-PAMAM solution and PVA solution. PBA-PAMAM/PVA films were constructed successfully through the formation of boronate ester bonds between the boronic acid moiety in PBA and 1,3-diol units in PVA. When the (PBA-PAMAM/PVA)(5)films were immersed in rose bengal (RB) solution, RB was adsorbed onto the LbL films. The amount of RB adsorbed was higher in the LbL films immersed in acidic solution than in basic solution. The release of RB from the LbL films was also promoted in the basic solution, while it was suppressed in the acidic solution. The boronic acid ester is oxidized to phenol by hydrogen peroxide (H2O2) and the carbon-boron bond is cleaved, so that the (PBA-PAMAM/PVA)(5)films can be decomposed by immersion in H(2)O(2)solution. Therefore, when RB-adsorbed (PBA-PAMAM/PVA)(5)films were immersed in H(2)O(2)solution, the release of RB was moderately promoted when the solution was weakly acidic.

引用

页数：14

共 32 条

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