Interfacial adsorption of polymers and surfactants:: Implications for the properties of disperse systems of pharmaceutical interest

被引：66

作者：

Duro, R ^{[1
]}

Souto, C ^{[1
]}

Gómez-Amoza, JL ^{[1
]}

Martínez-Pacheco, R ^{[1
]}

Concheiro, A ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15706, Spain

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 07期

关键词：

D O I：

10.1081/DDC-100102244

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review considers basic aspects of the interfacial adsorption of polymers and surfactants, with particular reference to the relevance of these processes for the formulation of pharmaceutical disperse systems. First, we discuss different approaches to the interpretation of adsorption isotherms, paying particular attention to sytems containing more than one adsorbate. Second we consider the implications of adsorption for the properties of suspensions, emulsions, and colloidal systems, particularly as regards the use of polymers and surfactants for stabilizing disperse systems, for controlling flocculation, and for modifying the biopharmaceutical behavior of colloidal drug carriers. Finally, we present a number of representative examples of the importance of adsorption of macromolecules in pharmaceutical systems.

引用

页码：817 / 829

页数：13

共 149 条

[1] Dynamics of initial stage flocculation of polystyrene latex spheres with polyelectrolytes [J].