Phenolic derivatives and an antifungal and cytototoxic labdane diterpenoid from the root bark of Turraeanthus mannii

被引：10

作者：

Sielinou, Valerie Tedjon ^{[2
,3
]}

Vardamides, Juliette Catherine ^{[1
]}

Nkengfack, Augustin Ephrem ^{[2
]}

Laatsch, Hartmut ^{[3
]}

机构：

[1] Univ Douala, Dept Chem, Douala, Cameroon

[2] Univ Yaounde I, Dept Organ Chem, Yaounde, Cameroon

[3] Univ Gottingen, Inst Organ & Biomol Chem, Gottingen, Germany

来源：

PHYTOCHEMISTRY LETTERS | 2012年 / 5卷 / 03期

关键词：

Turraeanthus mannii; Meliaceae; Labdane diterpene; Phenolic derivatives; Antifungal activity; Cytotoxic activity;

D O I：

10.1016/j.phytol.2012.05.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The structures of two new compounds from the root bark of Turraeanthus mannii (Meliaceae) were determined as (3R,4R,3'R,4'R)-6,6'-dimethoxy-3,4,3',4'-tetrahydro-2H,2'H-[3,3']bichromenyl-4,4'-diol (1) and 15-acetoxy-labda-8(17), 12E, 14Z-trien-16-al (2) by means of spectroscopic analysis. Five further known compounds including one coumarin derivative, one chromenone, two labdane diterpenes and one pregnane steroid have been isolated from the same source. In antifungal and cytotoxic assays, 15-acetoxy-labda-8(17), 12E, 14Z-trien-16-al (2) was highly active against Mucor miehei and Artemia salina, respectively. (C) 2012 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

引用

页码：409 / 413

页数：5

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