Dysregulated Tim-3 expression and its correlation with imbalanced CD4 helper T cell function in ulcerative colitis

被引：43

作者：

Shi, Fengmin ^{[1
,2
]}

Guo, Xiaoqin ^{[2
]}

Jiang, Xingwei ^{[2
]}

Zhou, Ping ^{[1
]}

Xiao, Yan ^{[3
]}

Zhou, Tingting ^{[2
]}

Chen, Guojiang ^{[2
]}

Zhao, Zhi ^{[2
]}

Xiao, He ^{[2
]}

Hou, Chunmei ^{[2
]}

Li, Xinying ^{[2
]}

Yang, Xiaomei ^{[2
]}

Wang, Renxi ^{[2
]}

Feng, Jiannan ^{[2
]}

Shen, Beifen ^{[2
]}

Li, Yan ^{[2
]}

Han, Gencheng ^{[2
]}

机构：

[1] Gen Hosp AF China, Dept Gastroenterol, Beijing 100142, Peoples R China

[2] Inst Basic Med Sci, Dept Mol Immunol, Beijing 100850, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Resp Med, Beijing 100037, Peoples R China

来源：

CLINICAL IMMUNOLOGY | 2012年 / 145卷 / 03期

关键词：

Ulcerative colitis; Immune regulation; Tim-3; Gal-9; T help cells; INFLAMMATORY-BOWEL-DISEASE; TH17; CELLS; IMMUNITY; AUTOIMMUNE; DIFFERENTIATION; GENERATION; PROMOTES; INNATE; FAMILY; GAMMA;

D O I：

10.1016/j.clim.2012.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The pathogenesis of ulcerative colitis (UC) remains largely unclear. Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls. In addition to an enhanced Th17 response and attenuated regulatory T (Treg) cell response, there was also a significantly decreased Th1 response in UC. Levels of the Th1 cell chemokines CXCL9 and CXCL10 were significantly decreased in UC mice, partially explaining the decreased Th1 cell function in UC. Finally, administration of a putative antagonistic anti-Tim-3 antibody or of recombinant Gal-9 significantly exacerbated or attenuated DSS-induced colitis by altering the balance between different Th cell subsets. Our data suggest that a dysregulated Tim-3/Gal-9 pathway may contribute to the pathogenesis of UC. A better understanding of this pathway may shed new light on the pathogenesis of this disease. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：230 / 240

页数：11

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