Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas

被引：6
作者：
Calle, Catarina [1 ,2 ]
Kuba, Maria Gabriela [1 ]
Brogi, Edi [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10065 USA
[2] Univ Beira Interior, Fac Ciencias Saude, Covilha, Portugal
来源：
BREAST JOURNAL | 2020年 / 26卷 / 06期
关键词：
atypical lobular hyperplasia (ALH); florid lobular carcinoma in situ (FLCIS); lobular carcinoma in situ (LCIS); pleomorphic lobular carcinoma in situ (PLCIS); upgrade; CARCINOMA IN-SITU; CORE BIOPSY; FOLLOW-UP; INTRAEPITHELIAL NEOPLASIA; PATHOLOGICAL FINDINGS; OUTCOMES; RISK; EXPERIENCE; EXCISION; NECROSIS;
D O I：
10.1111/tbj.13857
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. We also review imaging features, management at core needle biopsy, upgrade rates at surgical excision, and clinical management dilemmas.
引用
收藏
页码：1148 / 1155
页数：8
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