Recent Progress in Enzymatic Synthesis of Sugar Nucleotides

被引:28
作者
Cai, Li [1 ]
机构
[1] Univ S Carolina Salkehatchie, Walterboro, SC 29488 USA
关键词
Sugar nucleotides; Enzymatic synthesis; Carbohydrates; Glycosyltransferase; UDP-GLUCURONIC ACID; EFFICIENT CHEMOENZYMATIC SYNTHESIS; RECOMBINANT ESCHERICHIA-COLI; GDP-L-FUCOSE; URIDINE DIPHOSPHOGLUCOSE DEHYDROGENASE; FUNGUS CRYPTOCOCCUS-NEOFORMANS; LARGE-SCALE SYNTHESIS; N-ACETYLGLUCOSAMINE; ACTIVE-SITE; SUBSTRATE-SPECIFICITY;
D O I
10.1080/07328303.2012.687059
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Glycosylation is one of the most important reactions in nature as it results in the formation of glycoconjugates with diverse biological functions. Sugar nucleotides serve as the natural donor molecules for the biosynthesis of such glycoconjugates and other carbohydrates. Furthermore, these donor molecules are also indispensable building blocks for the enzymatic synthesis of carbohydrates in vitro using Leloir-type glycosyltransferases. Given such importance, the biosynthetic pathways of sugar nucleotides have been exploited, enabling the development of both chemical and enzymatic approaches to produce these molecules. A survey of recent progress in enzymatic synthesis of common mammalian sugar nucleotides as well as their derivatives is thus presented. As a popular strategy, conjugation of sugar nucleotide synthesis with glycosyltransfer reactions and in vivo production of sugar nucleotides are also included.
引用
收藏
页码:535 / 552
页数:18
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