Bone quality beyond bone mineral density - new diagnostic perspectives by quantitative ultrasound

被引：0
|
作者：
Raum, K. [1 ,2 ]
Rohrbach, D. [1 ,2 ]
Laugier, P. [3 ]
Glueer, C-C [4 ]
Barkmann, R. [4 ]
机构：
[1] Charite, Julius Wolff Inst, D-13353 Berlin, Germany
[2] Charite, Berlin Brandenburg Sch Regenerat Therapies, D-13353 Berlin, Germany
[3] Univ Paris 06, Lab Imagerie Parametr, Paris, France
[4] Univ Klinikum Schleswig Holstein, Radiol Diagnost Klin, Kiel, Germany
来源：
OSTEOLOGIE | 2010年 / 19卷 / 03期
关键词：
Acoustic microscopy; acoustic impedance; axial transmission; elasticity; stiffness; fracture risk; bone quality; bone mineral density; osteoporosis; quantitative ultrasound; speed of sound; SCANNING ACOUSTIC MICROSCOPY; HIP FRACTURE RISK; CORTICAL BONE; AXIAL TRANSMISSION; HIGH-RESOLUTION; MECHANICAL-PROPERTIES; CALLUS DISTRACTION; TISSUE ELASTICITY; TRABECULAR BONE; T-SCORES;
D O I：
暂无
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
Osteoporosis is a skeletal disease that is only partially explained by variations in bone mineral density. Bone quality is determined by a variety of compositional and ultra-structural properties of the mineralized tissue matrix. In contrast to x-ray based methods, the interaction of acoustic waves with bone tissue generates information on the elastic and structural properties of this tissue. Quantitative ultrasound (QUS) is a first class alternative to ionizing x-ray based assessment of fracture risk. New methods measure at fragile anatomical regions, e. g. the distal radius and the proximal femur. Experimentally, ultrasound frequencies up to the GHz range allow an "elastic view" into the lamellar bone structure. The potential of high resolution microelastic images measured by scanning acoustic microscopy in combination with numerical sound propagation simulations for the optimization and validation of novel QUS methods will be discussed.
引用
收藏
页码：217 / 224
页数：8
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