Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review

被引：14

作者：

Niitsu, Takayuki ^{[1
]}

Shiroyama, Takayuki ^{[1
]}

Miyake, Kotaro ^{[1
]}

Noda, Yoshimi ^{[1
]}

Kido, Kansuke ^{[2
]}

Hara, Reina ^{[1
]}

Enomoto, Takatoshi ^{[1
]}

Adachi, Yuichi ^{[1
]}

Amiya, Saori ^{[1
]}

Suga, Yasuhiko ^{[1
]}

Fukushima, Kiyoharu ^{[1
]}

Koyama, Shohei ^{[1
]}

Iwahori, Kota ^{[1
]}

Hirata, Haruhiko ^{[1
]}

Nagatomo, Izumi ^{[1
]}

Takeda, Yoshito ^{[1
]}

Kumanogoh, Atsushi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Resp Med & Clin Immunol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Pathol, Osaka, Japan

来源：

THORACIC CANCER | 2020年 / 11卷 / 12期

关键词：

Alectinib; ALK; combined small cell carcinoma; immunochemotherapy; literature review; FACTOR RECEPTOR MUTATIONS; CANCER PATIENTS; ADENOCARCINOMA; TRANSFORMATION; FEATURES; FUSION; SCLC;

D O I：

10.1111/1759-7714.13716

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Combined small cell lung cancer (c-SCLC) is a relatively rare subtype of SCLC and is defined by the combination of SCLC and any elements of non-small cell carcinoma (NSCLC). Standard chemotherapy for patients with c-SCLC has not yet been established. Gene mutations such as epidermal growth factor receptor (EGFR) mutations may be detected in patients with c-SCLC. However, little is known about anaplastic lymphoma kinase (ALK) rearrangement in c-SCLC patients. Here, we report a young female patient who was successfully treated with alectinib for ALK-positive c-SCLC after failure of immunochemotherapy for SCLC and cytotoxic chemotherapy for adenocarcinoma. Moreover, we performed a literature review of EGFR- or ALK-positive c-SCLC patients. Our report suggests that ALK testing may be justified in patients with SCLC that contain an adenocarcinoma component. Key points Significant findings of the study center dot This is the first report describing the treatment course comprising immunochemotherapy and ALK-TKI in a patient with c-SCLC harboring ALK rearrangement. What this study adds center dot Our case and literature review suggest that although ALK mutation is rare in patients with c-SCLC, its identification and treatment with ALK-TKIs may contribute to clinical benefits.

引用

页码：3625 / 3630

页数：6