Studies and X-ray Determinations with 2-(Acetonylthio)benzothiazole: Synthesis of 2-(Benzothiazol-2-ylthio)-1-phenylethanone and 2-(Acetonylthio)Benzothiazole by C-S Bond Cleavage of 2-(Acetonylthio)benzothiazole in KOH

被引：5
作者：
Al-Omran, Fatima [1 ]
Abou El-khair, Adel [1 ]
机构：
[1] Kuwait Univ, Dept Chem, Fac Sci, Safat 13060, Kuwait
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 01期
关键词：
DERIVATIVES; THIOPHENE; PYRIDINE; AGENTS;
D O I：
10.1002/jhet.1693
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New route for the synthesis of 2-(benzothiazol-2-ylthio)-1-phenylethanone (6) and 2-(acetonylthio)benzothiazole (1) by using phenacyl bromide and -chloroacetone, respectively, through carbon-sulfur bond cleavage reactions in a basic medium has been generated. Treatment of 1 with malononitrile and elemental sulfur afforded the corresponding derivative of 2-amino-3-cyanothiophene (12), whereas treatment of 1 with cyanoacetohydrazide afforded the corresponding derivative of cyanoacetylhydrazone derivative (13). The structure of the synthesis compounds has been established on the basis of elemental analyses, H-1-NMR, C-13-NMR, correlation spectroscopy, heteronuclear single quantum coherence, MS spectra, and X-ray crystallographic investigations.
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页码：62 / 70
页数：9
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