Discovery of a new class of antiviral compounds: Camphor imine derivatives

被引：86

作者：

Sokolova, Anastasiya S. ^{[1
,2
]}

Yarovaya, Olga I. ^{[1
,2
]}

Shernyukov, Andrey V. ^{[1
]}

Gatilov, Yuriy V. ^{[1
,2
]}

Razumova, Yuliya V. ^{[2
]}

Zarubaev, Vladimir V. ^{[3
]}

Tretiak, Tatiana S. ^{[3
]}

Pokrovsky, Andrey G. ^{[2
]}

Kiselev, Oleg I. ^{[3
]}

Salakhutdinov, Nariman F. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

[3] Influenza Res Ctr, Dept Chemotherapy, St Petersburg 197376, Russia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 105卷

基金：

俄罗斯基础研究基金会; 俄罗斯科学基金会;

关键词：

Influenza; Camphor derivatives; Antiviral; Cage compounds; IN-VITRO; INFLUENZA; VIRUS; AGENTS; ANTIINFLUENZA; RESISTANCE; INHIBITORS; MEMBRANE; DESIGN;

D O I：

10.1016/j.ejmech.2015.10.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：263 / 273

页数：11

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