The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

被引：26
作者：
Dale, CS
Gonçalves, LRC
Juliano, L
Juliano, MA
da Silva, AMM
Giorgi, R
机构：
[1] Butantan Inst, Lab Pathophysiol, BR-05503900 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Inst Pharmacol, Dept Biophys, BR-04044020 Sao Paulo, Brazil
[3] Butantan Inst, Immunopathol Lab, BR-05503900 Sao Paulo, Brazil
来源：
PEPTIDES | 2004年 / 25卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
hyperalgesia; edema; jararhagin; papain; MRP-14; S100A9;
D O I：
10.1016/j.peptides.2003.12.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：81 / 89
页数：9
相关论文
共 63 条
  • [41] ISOLATION IF A YAC CLONE COVERING A CLUSTER OF 9 S100 GENES ON HUMAN-CHROMOSOME-1Q21 - RATIONALE FOR A NEW NOMENCLATURE OF THE S100 CALCIUM-BINDING PROTEIN FAMILY
    SCHAFER, BW
    WICKI, R
    ENGELKAMP, D
    MATTEI, MG
    HEIZMANN, CW
    [J]. GENOMICS, 1995, 25 (03) : 638 - 643
  • [42] Inhibition of Candida albicans growth by calprotectin in the absence of direct contact with the organisms
    Sohnle, PG
    Hahn, BL
    Santhanagopalan, V
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (06) : 1369 - 1372
  • [43] Zinc-reversible antimicrobial activity of recombinant calprotectin (migration inhibitory factor-related proteins 8 and 14)
    Sohnle, PG
    Hunter, MJ
    Hahn, B
    Chazin, WJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (04) : 1272 - 1275
  • [44] Sokal R.R., 1981, BIOMETRY, P859
  • [45] ANTIMICROBIAL ACTIONS OF CALCIUM-BINDING LEUKOCYTE L1 PROTEIN, CALPROTECTIN
    STEINBAKK, M
    NAESSANDRESEN, CF
    LINGAAS, E
    DALE, I
    BRANDTZAEG, P
    FAGERHOL, MK
    [J]. LANCET, 1990, 336 (8718) : 763 - 765
  • [46] Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism
    Steinhoff, M
    Vergnolle, N
    Young, SH
    Tognetto, M
    Amadesi, S
    Ennes, HS
    Trevisani, M
    Hollenberg, MD
    Wallace, JL
    Caughey, GH
    Mitchell, SE
    Williams, LM
    Geppetti, P
    Mayer, EA
    Bunnett, NW
    [J]. NATURE MEDICINE, 2000, 6 (02) : 151 - 158
  • [47] EFFECTS OF SL-1010 (SODIUM HYALURONATE WITH HIGH-MOLECULAR-WEIGHT) ON EXPERIMENTAL OSTEOARTHRITIS INDUCED BY INTRAARTICULARLY APPLIED PAPAIN IN GUINEA-PIGS
    TANAKA, H
    KITOH, Y
    KATSURAMAKI, T
    TANAKA, M
    KITABAYASHI, N
    FUJIMORI, S
    UMEMOTO, J
    NAMBA, K
    [J]. FOLIA PHARMACOLOGICA JAPONICA, 1992, 100 (01) : 77 - 86
  • [48] HYPERALGESIA INDUCED BY BOTHROPS-JARARACA VENOM IN RATS - ROLE OF EICOSANOIDS AND PLATELET-ACTIVATING-FACTOR (PAF)
    TEIXEIRA, CFP
    CURY, Y
    OGA, S
    JANCAR, S
    [J]. TOXICON, 1994, 32 (04) : 419 - 426
  • [49] PHARMACOLOGICAL EVALUATION OF RAT PAW EDEMA INDUCED BY BOTHROPS JARARACA VENOM
    TREBIEN, HA
    CALIXTO, JB
    [J]. AGENTS AND ACTIONS, 1989, 26 (3-4): : 292 - 300
  • [50] Protease-activated receptors in inflammation, neuronal signaling and pain
    Vergnolle, N
    Wallace, JL
    Bunnett, NW
    Hollenberg, MD
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (03) : 146 - 152
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