Controlled ice nucleation in the field of freeze-drying: Fundamentals and technology review

被引：140
作者：
Geidobler, R. [1 ]
Winter, G. [1 ]
机构：
[1] Univ Munich, Dept Pharm, D-81377 Munich, Germany
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2013年 / 85卷 / 02期
关键词：
Freeze-drying; Lyophilization; Ice nucleation; Controlled nucleation; SUPERCOOLED WATER; PHASE-SEPARATION; ACTIVE CONTROL; LYOPHILIZATION; MORPHOLOGY; CRYSTALS; CRYSTALLIZATION; PHARMACEUTICALS; TEMPERATURE; MOISTURE;
D O I：
10.1016/j.ejpb.2013.04.014
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In the scientific community as well as in commercial freeze-drying, controlled ice nucleation has received a lot of attention because increasing the ice nucleation temperature can significantly reduce primary drying duration. Furthermore, controlled ice nucleation enables to reduce the randomness of the ice nucleation temperature, which can be a serious scale-up issue during process development. In this review, fundamentals of ice nucleation in the field of freeze-drying are presented. Furthermore, the impact of controlled ice nucleation on product qualities is discussed, and methods to achieve controlled ice nucleation are presented. (C) 2013 Elsevier B.V. All rights reserved.
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收藏
页码：214 / 222
页数：9
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