Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells

被引：40

作者：

Baehs, Sebastian ^{[1
]}

Herbst, Andreas ^{[1
]}

Thieme, Susanne E. ^{[2
]}

Perschl, Claudia ^{[1
]}

Behrens, Andrea ^{[1
]}

Scheel, Silvio ^{[3
]}

Jung, Andreas ^{[3
]}

Brabletz, Thomas ^{[4
]}

Goeke, Burkhard ^{[1
]}

Blum, Helmut ^{[2
]}

Kolligs, Frank T. ^{[1
]}

机构：

[1] Univ Munich, Klinikum Grosshadern, Dept Med 2, D-81377 Munich, Germany

[2] Univ Munich, Gene Ctr, LAFUGA, D-81377 Munich, Germany

[3] Univ Munich, Inst Pathol, D-80337 Munich, Germany

[4] Univ Freiburg, Dept Surg, D-79095 Freiburg, Germany

来源：

CANCER LETTERS | 2009年 / 276卷 / 02期

关键词：

beta-catenin; Wnt; Dickkopf; DKK4; Colorectal cancer; WNT SIGNALING PATHWAY; HUMAN COLON-CANCER; EPIGENETIC INACTIVATION; BETA-CATENIN/TCF; FAMILY; GENES; MUTATIONS; TARGET;

D O I：

10.1016/j.canlet.2008.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal beta-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：152 / 159

页数：8

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