Microfluidic Sedimentation System for Separation of Plasma from Whole Blood

被引：0
作者：
Kuroda, Chiaki [1 ]
Ohki, Yoshimichi [1 ,2 ]
Ashiba, Hiroki [3 ]
Fujimaki, Makoto [3 ]
Awazu, Koichi [3 ]
Tanaka, Torahiko [4 ]
Makishima, Makoto [4 ]
机构：
[1] Waseda Univ, Dept Elect Engn & Biosci, Tokyo, Japan
[2] Waseda Univ, Res Inst Mat Sci & Technol, Tokyo, Japan
[3] Natl Inst Adv Ind Sci & Technol, Elect & Photon Res Inst, Tsukuba, Japan
[4] Nihon Univ, Sch Med, Div Biochem, Dept Biomed Sci, Tokyo, Japan
来源：
2014 IEEE SENSORS | 2014年
基金：
日本科学技术振兴机构;
关键词：
plasma extraction; microfluidics; sedimentation; blood; EXTRACTION;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
A microfluidic system for a portable and speedy blood test device has been developed. In the system, blood is injected into a cylindrical channel with a diameter of 3.0 mm and a height of 3.0 mm from the bottom to the top. When the blood ascends the channel, blood cells sediment at the bottom and plasma is separated at the top. This system can be manufactured easily at a low cost by simply bonding two identical polydimethylsiloxane chips. Pure plasma can be obtained successfully from a very tiny amount of blood, less than a drop (9 mu L).
引用
收藏
页码：1854 / 1857
页数：4
相关论文
共 12 条
  • [1] Microfiltration platform for continuous blood plasma protein extraction from whole blood during cardiac surgery
    Aran, Kiana
    Fok, Alex
    Sasso, Lawrence A.
    Kamdar, Neal
    Guan, Yulong
    Sun, Qi
    Uendar, Akif
    Zahn, Jeffrey D.
    [J]. LAB ON A CHIP, 2011, 11 (17) : 2858 - 2868
  • [2] Magnetically-actuated blood filter unit attachable to pre-made biochips
    Chung, Kwang Hyo
    Choi, Yo Han
    Yang, Jong-Heon
    Park, Chan Woo
    Kim, Wan-Joong
    Ah, Chil Seong
    Sung, Gun Yong
    [J]. LAB ON A CHIP, 2012, 12 (18) : 3272 - 3276
  • [3] Dimov IK, 2011, LAB CHIP, V11, P845, DOI [10.1039/c0lc00403k, 10.1039/c01c00403k]
  • [4] DOBASHI T, 1987, BIORHEOLOGY, V24, P153
  • [5] Dobashi T., 1990, BIORHEOLOGY, V4, P109
  • [6] A microfluidic chip for blood plasma separation using electro-osmotic flow control
    Jiang, Hai
    Weng, Xuan
    Chon, Chan Hee
    Wu, Xudong
    Li, Dongqing
    [J]. JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 2011, 21 (08)
  • [7] Micro-scale blood plasma separation: from acoustophoresis to egg-beaters
    Kersaudy-Kerhoas, Maiwenn
    Sollier, Elodie
    [J]. LAB ON A CHIP, 2013, 13 (17) : 3323 - 3346
  • [8] Validation of a blood plasma separation system by biomarker detection
    Kersaudy-Kerhoas, Maiwenn
    Kavanagh, Deirdre M.
    Dhariwal, Resham S.
    Campbell, Colin J.
    Desmulliez, Marc P. Y.
    [J]. LAB ON A CHIP, 2010, 10 (12) : 1587 - 1595
  • [9] Acoustic Whole Blood Plasmapheresis Chip for Prostate Specific Antigen Microarray Diagnostics
    Lenshof, Andreas
    Ahmad-Tajudin, Asilah
    Jaras, Kerstin
    Sward-Nilsson, Ann-Margret
    Aberg, Lena
    Marko-Varga, Gyorgy
    Malm, Johan
    Lilja, Hans
    Laurell, Thomas
    [J]. ANALYTICAL CHEMISTRY, 2009, 81 (15) : 6030 - 6037
  • [10] Fast and continuous plasma extraction from whole human blood based on expanding cell-free layer devices
    Sollier, Elodie
    Cubizolles, Myriam
    Fouillet, Yves
    Achard, Jean-Luc
    [J]. BIOMEDICAL MICRODEVICES, 2010, 12 (03) : 485 - 497
12